PPT-Toxicology : Subacute and Chronic Toxicity

BPharm Sixth Sem BP602T Subacute Toxicity Subacute toxicity studies are intended to evaluate a drugs toxic potential and pathological effects following a treatment repeated administration. Topics for Principles of Toxicology: Part B. Endocrine Toxicity. Carcinogenicity. Neurotoxicity. Persistence and Bioaccumulation. The topics for “Part C” (what we could not cover). Summary. The systemic problem. Lecture 1: Principles of Toxicology. Principles of Toxicity. Defining toxicology. History of toxicology. Dose response. Evaluating safety. Toxicology. Toxicology is the study of adverse effects of . chemicals . 2. Toxicology. Toxicology. —. the study of the adverse effects of chemicals or physical agents on living organisms. Types:. Environmental. —. air, water, soil. Consumer. —. foods, cosmetics, drugs. Week 2:. Organophosphate . Insecticides. a. Acute toxicity. History. World War II nerve gases. Britain. Germany. Gerhard Schrader. TEPP as first commercial OP insecticide. Post-WWII transfer of IG Farben chemicals to US. The Study of Poisons. Beginning the Journey into. Toxicology. Murder Magic and Medicine. The Goals of this course. Introduce the Principles of Toxicology. Part A. History of Toxicology. Dose-response. Poornima Kandasamy. 1,. Ajita Sasidharan. 1. 1. Glaucoma, Sankara eye hospital, Coimbatore, India. . INTRODUCTION: . Headache is one of the most common symptoms of subacute angle closure attack.. Harmful Effects of Toxicology. It may damage the survival or normal functions of an individual.. What is Toxicity?. The degree to which a substance is poisonous or can cause injury.. The toxicity depends on a variety of factors.. OCCUPATIONAL MEDICINE SPECIALIST. PHYSIOLOGY. Regulation of electrolytes . Maintenance of acid-base balance. Regulation of BP . Remove wastes from the blood. Reabsorption. of H2O,G,AA. Produce hormones. Absorption of toxins in the GIT is by passive diffusion – this process requires that the substance cross cellular barriers . Toxins that are not absorbed from the GIT do not produce systemic effects but may produce local effects – diarrhea, bleeding and malabsorption of nutrients . Announcements I. Return HW and Group Assignments. Turn in Toxicology HW (last homework). Today’s Group Assignment on Alternative Fuel and Toxicology. Final Exam . Scheduled for Wednesday, 5/20 5:15 to 7:15 PM. Organophosphate . Insecticides. a. Acute toxicity. Categories of Effects. Muscarinic. Mimic action of muscarine. Peripheral nervous system only. Smooth muscle, heart, exocrine glands. Bronchoconstriction, salivation, lacrimation, perspiration. Profesor Farmakologi. Departemen Farmakologi Dan Terapi . Fakultas Kedokteran UA. Pharmacology : Dogma and Reason. Ancient Beginnings. - Religious /magical. Hippocrates ( ~ 460 BC). - Observation / experience. Toxicosis. VMD-610 Dr. Anil Kumar. Asst. Professor. Dept. of VCC, BVC, Patna. INTRODUCTION. Toxicology:. The branch of science which deals with the harmful effects of physical and chemical agents on human and animal life.. Brenda J. Gehrke, Ph.D.. Office of New Drugs/CDER/FDA. November 2016. Abbreviations. ADME. : absorption, distribution, metabolism, excretion. HU. : hydroxyurea. IB. : Investigator Brochure. ICH. : International Council for .