67 No 3 pp 21757585223 2010 ISSN 00016837 Polish Pharmaceutical Society Over the past few decades significant medical advances have been made in the area of drug deliv ery with the development of controlled release dosage forms There are large varie ID: 25235
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218SUVAKANTA DASH et al.Fundamentals of kinetics of drug releaseWhitney in 1897 as the equation(10):),where Cconcentration at timet and CNernst and BrunnerFilm Theory in vitrooance] (13, 14).Model dependent methods (zero order, firstorder, Higuchi, Korsmeyer-Peppas model,HixsonHixsontor (f1), similarity factor (f2) (17-19)]. Statistical methodsExploratory Data Analysis methodsMultivariate approach (MANOVA)These methods were based upon repeatedIn repeated measures, ANOVA containing 220SUVAKANTA DASH et al.HixsonñCrowell modelt ÖÖÖÖ(10)(kappa)is a constant incorporating the sur-in vitroKorsmeyer-Peppas modelin vitro Baker-Lonsdale model3 Mt = ñññ 1 ñ (1 ñ ñññ)= ñññ 1 ñ (1 ñ ñññ)M in vitro o (Mt / M)] / dt with respect to the root of timeinverse. Application: This equation has been used to thelinearization of release data from several formula-tions of microcapsules or microspheres (40, 41).Weibull modelñ ñññññññ ññññññ1 ñ e Release exponent (n) Drug transport mechanism Rate as a function of time 0.5 Fickian diffusiont0.45 Non -Fickian transport t 0.89 Case II transport Zero order release Higher than 0.89 Super case II transport t 222SUVAKANTA DASH et al.Non linearregression models Model Independent Approach Using a Similarityoach Using a Similarity t=1n(Rtñ Tt)]/[ t=1nRt]} 100(24)1.Anonymous: Fed. Register 42, 1642 (1977). 2.Medical applications of controlled release,3.Controlled drug delivery, Robinson J.R., Lee,4.Modeling and data treatment in the pharma-5.Israel G.: in Modelli matematici nelle scienzeVenti, Urbino1998.6.Hintz R.J., Johnson K.C.: Int. J. Pharm. 51, 97.Ozturk S.S., Palsson B.O., Donohoe B.,8.Dressman J.B., Fleisher D.: J. Pharm. Sci. 75,9.Dressman J.B., Fleisher D., Amidon G.L.: J.10.Noyes A.A., Whittney W.R.: J. Am. Chem. Soc.11.Nernst W.: Z. Physik. Chem. 47, 52 (1904).12.Brunner E.: Z. Physik. Chem, 47, 56 (1904). 13.Mauger J.W., Chilko D., Howard, S.: DrugDev. Ind. Pharm. 12, 969 (1986). 14.Polli J.E., Rekhi G.S., Augsburger L.L., Shah15.Costa P., Lobo J.M.S.: Eur. J. Pharm. Sci., 13,16.Shah V.P., Lesko L.J., Fan J., Fleischer N.17.Costa P.: Int. J. Pharm., 220, 77 (2001). 18.Moore J.W. Flanner H.H.: Pharm. Technol., 20,