PDF-Ann.N.Y.Acad.Sci.ISSN0077-8923

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ANNALSOFTHENEWYORKACADEMYOFSCIENCES IssueAnnals Reports Targetingepigeneticregulatorsforcancertherapy SusanWee 1 DashDhanak 2 HaitaoLi 3 ScottAArmstrong 4 RobertACopeland 5 RobertSims 6 Steph

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Ann.N.Y.Acad.Sci.ISSN0077-8923: Transcript

ANNALSOFTHENEWYORKACADEMYOFSCIENCES IssueAnnals Reports Targetingepigeneticregulatorsforcancertherapy SusanWee 1 DashDhanak 2 HaitaoLi 3 ScottAArmstrong 4 RobertACopeland 5 RobertSims 6 Steph. ANNALSOFTHENEWYORKACADEMYOFSCIENCES Issue: BlavatnikAwardsforYoungScientists Platetectonicsandplanetaryhabitability:currentstatus andfuturechallenges JunKorenaga DepartmentofGeologyandGeophysics,YaleU etal. Figure1.Thearti Proc.Nat.Acad.Sci.USA72(1975)hasalowerboundPI(tY1t+h)n(Y-&#x Tj ;&#x/F1 ;.9;� Tf;&#x 33.; T;&#xz -0;&#x.24 ;&#xTs 1;.10;&#x 0 T; 00;t+h*)1&#x Tj ;&#x/F1 ;.9;� Tf;&#x 33.;& Proc.Nat.Acad.Sci.USA91(1994)9761thepGEM4vector(Promega)forsequencing.Specifically,a1.2-kbPstIfragment,whichhybridizedtothemousecDNAprobe,butnottotalmouseDNA,wassubclonedtogeneratethesequencehomologou ANNALSOFTHENEWYORKACADEMYOFSCIENCES Issue: DNAHabitatsandTheirRNAInhabitants Prefaceto DNAHabitatsandTheirRNAInhabitants WhenIturnedmyfocusfromdebatesonthephilosophyofsciencetothephilosophyofbiologyan ANNALSOFTHENEWYORKACADEMYOFSCIENCES Issue: TheNeurosciencesandMusicIV:LearningandMemory Becomingmusicallyenculturated:effectsofmusicclasses forinfantsonbrainandbehavior LaurelJ.Trainor, 1 , 2 C MedicalSciences:Cherif-Zaharetal.Proc.Natl.Acad.Sci.USA87(1990)6245aatcccggcctgcacagagacggacacaggATGAGCTCTAAGTACCCGCGGTCTGTCCGG60MetSerSerLysTyrProArgSerValArg9CGCTGCCTGCCCCTCTGGGCCCTAACACTGGAAGCAGCTC 868CellBiology:OsbornandWeberFIGS.1-7.(Legendappearsatbottomofthefollowingpage.)Proc.Nat.Acad.Sci.USA73(1976) Proc.Nat.Acad.Sci.USA73(1976)869FIG.8.Recoveryofcytoplasmicmicrotubulesin3T3cellsafterColc Proc.Natl.Acad.Sci.USA75(1978)RESULTSWhennormalhumanglobinDNAwasdigestedwithEcoRIandprobedwithamixtureofa-and(3-globincDNAs,fivemajorfragmentswereseen(Fig.1).Thelargestfragment,about21kilobases(kb)inl Dew&CabezaRelationshipbetweenexplicitandimplicitmemoryTable1.Thetraditionalmodel,highlightingthecriticalfeaturesusedtodichotomizeexplicitandimplicitformsofmemory Memoryphenomenon FeatureImplicitExplic I,fromFlavobacteriumokeanokoites,isamemberoftheunusual,typeIIsclassofrestrictionendonucleasesthatrec-ognizeaspecificDNAsequenceandcleavenonspecificallyashortdistanceawayfromthatsequence(1).Ibindstheco Genetics:Slupskaetal.Table1.ComparisonofmutAandmutCwithmutA,CStrainLac+revertantsper(CC105)108cells,no.+2.3 Cellsrespondtodevelopmentalcuesandenvironmentalstimulibyalteringgeneexpression.Often,transmissionofdifferentupstreamsignalsinvolvescommoncomponentsyetelicitsdistinct(butappropriate)outcomes.Numerousag Proc.Natl.Acad.Sci.USA82(1985)ofcellsoveriodinevapors.Cellsthataccumulateglycogenstainbrown,whereasthosethatdon'tremainyellow.Quan-titativetrehaloseandglycogendeterminationsweremadeaccordingtoLilliean

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