PPT-Hallmarks of Cancer Stem Cells

Recurrence and Metastasis A Major Factor in Cancerrelated Deaths Cancer is the second leading cause of death in the United States 1 Despite advances in cancer treatment many patients develop. More than 200 different types of cancer have been identified. What is cancer?. CANCER. Defining cancer. Cancer is an accumulation of abnormal cells that multiply through uncontrolled cell division and spread to other parts of the body by invasion and/or distant metastasis via the blood and lymphatic . Clonal Tides in Multiple Myeloma. Linda M. Pilarski. University of Alberta, . Canada. 23 October 2014. Essential to change the focus from screening only the plasma cell (PC) compartment of MM to looking at the . , PC. The clonal evolution of tumor cell populations. . Science. (1976) 194:23-28. . Cavenee. , WK & White, RL. The genetic basis of cancer. . Scientific American . (1995) 272:72-79.. Emergence of a cancer cell. College Level . Kirsten Artwohl. What is cancer?. Simply stated, cancer is the uncontrolled growth of abnormal cells in the body.. Multi Hit Hypothesis. Cancer is typically a disease of old age. It requires a succession of greater than four events that each have a low probability.. Haematopoiesis. and Immunity. Afshin. . Raouf. Ph. 787-2294. raouf@cc.umanitoba.ca. Outline. What is immunity?. What is . haematopoiesis. ?. How does . haematopoiesis. maintain immunity?. in vivo and in vitro assays to study . Naralys. Batista. January 7, 2014. Funding for this. workshop was . provided by the program “Computational Modeling and Analysis of Complex Systems,” an NSF Expedition in Computing (Award Number 0926200).. Haematopoiesis. and Immunity. Afshin. . Raouf. Ph. 787-2294. raouf@cc.umanitoba.ca. Outline. What is immunity?. What is . haematopoiesis. ?. How does . haematopoiesis. maintain immunity?. in vivo and in vitro assays to study . Evolution of a Species. is the change in . the . inherited characteristics of biological populations over successive generations. . Evolutionary processes give rise to diversity at every level of biological organization, including species, individual organisms and molecules such as DNA and proteins.. Cheng-En Lai. BIOE 506: Molecular and Cellular Bioengineering. 4/25/2011. Overview. Background. Stem Cells. Signaling Pathways. Transforming Growth Factor-. β. (TGF-. β. ). SMAD Signaling Pathway. Non-Toxic Targeted Cancer Therapies. Jeffrey Dach MD. 7450 Griffin Road Suite 190. Davie, FL 33021. 954-792-4663. www.jeffreydachmd.com. Slides . Available At. : http://www.jeffreydachmd.com. Most of the Drugs . iPS. cells, self-renewal, differentiation, pluripotent, multipotent, Inner cell mass, Nuclear transfer (Therapeutic cloning), Feeder cells, LIF, embryoid body.. What are stem cells?. Cells that are able to renew themselves (. January 7, 2014. Funding for this. workshop was . provided by the program “Computational Modeling and Analysis of Complex Systems,” an NSF Expedition in Computing (Award Number 0926200).. Evolution of a Species. ” data, and data resources. Anthony Gitter. Cancer Bioinformatics (BMI 826/CS 838). January . 22, . 2015. What computational analysis contributes to cancer research. Predicting driver alterations. Defining properties of cancer (sub)types. . of. . cancer. :. Eight. . cancer. . hallmarks. and . two. . enabling. . factors. . (. genomic. . instability. and . tumor-promoting. . inflammation. ). . Most. . cancer. . cells. . acquire.