Risk Analysis ISOLDE NhâtTân VUONG 1 Swiss Federal Institute of Technology Lausanne Master student Chemical amp Biochemical Engineering Intership at CERN ID: 446395
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Nanoparticles Risk Analysis
ISOLDENhât-Tân VUONG
1Slide2
Swiss Federal Institute of Technology, Lausanne
Master
student, Chemical & Biochemical EngineeringIntership at CERNFor 5 monthsISOLDEEN-STI-RBS2Slide3
IntroductionNano-objects
At least 1dimension size ≤ 100 nm
Why are NanoParticles (NPs) so important ?New physical and chemical propertiesHigh Surface Area3Slide4
IntroductionApplications of nanotechnology
SuncreamPaintElectronics
Drug deliveryMaterial reinforcementCatalystsBiosensorsNanorobots4Slide5
ISOLDE : irradiation of
targets
in order to create a secondary ion beam Study the nuclei, medical applications, …Nano at ISOLDE : Nanoparticles are used (Y2O3) Nanoparticles are produced (CaO) Nano activity at ISOLDE
5Slide6
NanopowderWeight 1gPress to pellets
Pellets in a container Nano
activity at ISOLDE in a target6Slide7
DNA damagesRespiratory problems
Blood coagulationCardiovascular problems
Genotoxicity and cytotoxicityCellular deathNanoHazards7Slide8
Aim : Evaluate the risk and
implement appropriate prevention/protection measures
Simple model :Risk = Hazard x ExposureQuestion : How to quantify Hazard and Exposure ?Risk Analysis8Slide9
ContextNanotechnology = Emerging
technologyLack of information on NPs
Human toxicological effects are unknownSize make NPs difficult to detect/measure There are too many uncertainties It is difficult to quantify Hazard and Exposure Appropriate risk analysis method is requiredRisk Analysis9Slide10
Management of nanomaterials
safety
EPFL - Ecole Polytechnique Fédérale de Lausanne, Switzerland 2010Laboratory, Nano1 → Nano3«Control Banding» methodsSamuel Y. Paik and al. - Lawrence Livermore National Laboratory, CA, USA 2008ANSES - Agence Nationale de Sécurité Sanitaire, France 2011Control level, CL1 → CL5Risk Analysis - Methods10Slide11
Risk AnalysisConcept of «control banding
»11
Control Level = Hazard Band x Emission Potential BandControl level matrixSlide12
Hazard
Band assessment
HB1→ HB5Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDE12Slide13
Hazard
BandYttrium
Oxide Nanoparticles – which size ?Supplier : particles size 25-50 nmScanning Electron Microscope (SEM)13Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDESlide14
Hazard Band
Other analysis
Particle size distribution (PSD)Average particle size approx. 10 μmSpecific Surface Area (SSA, m2/g), BET methodAverage diameter approx. 68 nm14Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDESlide15
Hazard
Bandassessment
15Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDESlide16
Hazard
Band
AssessmentBulk Yttrium oxide-> HB316Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDEBulk Material Hazard Band ?(Original Band)Slide17
Hazard
Band assessment
Resulting Hazard BandHB517Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDEHB3
HB4HB5Slide18
Emission
Potential
Band assessmentResulting Exposure BandEP418Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDESlide19
Resulting Control Level
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Risk Analysis – ANSES Method i.e. Yttrium oxide at ISOLDECL5Highest risk levelRecommended measures :Full containmentSeek expert adviceSlide20
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Recommended
measures for a Nano3 lab :Technical measuresVentilationExtract air filtrationSASOrganizational measuresWaste double packagingTrainingWritten proceduresPersonal measuresProtective equipmentsCleaningWet cleaningRisk Analysis – EPFL Method Slide21
Prevention
/protection
measures at ISOLDERespiratory maskTyvek
suit2 pairs of glovesOvershoesGlasses
21Slide22
Three different methods gave a similar
result : Risk
level is very highBut Protection measures are different : EPFL method - Fume hoodvs« Control Banding » - Full process enclosure + Expert adviceComparison between 3 methods22Slide23
Nowadays :Toxicology of NPs are not
well knownExposure to
NPs is difficult to measureNext step for CERN : Choose one method and implement measuresFuture :Development of standards for Nanotechnologies → ISO TC 229 in progressOccupational risk managementISO/DTS 12901-1ISO/NP TS 12901-2Conclusion23Slide24
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Thank
you for your attention