PPT-CHEM133 Mass Spectrometry:

Lecture 1 4132017 Announcements Homework 22 Additional Problems Due Quiz Today after Announcements 418 Lecture will go back to rest of NMR interpretation examples and instrumentation then continue on Mass . chromatographyand.  mass spectrometry to identify different substances within a test sample. Applications of GC-MS include drug detection, environmental analysis, explosives investigation, and identification of unknown samples. GC-MS can also be used in airport security to detect substances in luggage or on human beings. Additionally, it can identify trace elements in materials that were previously thought to have disintegrated beyond identification..  . Brent Fultz. , California Institute of . Technology. Department of Applied Physics and Materials Science . <. AP. . |. . h. . |. . MS. >. History. Recoil-Free Fraction. Technique, Samples. Phil Charles. CCMP. Overview of Talk. Overview of proteomics as a concept. Techniques discussion. 2D Gels and experimental design paradigms. Proteomics mass spectrometry. Identification. Quantitation. Outline. Tandem Mass Spectrometry. De Novo Peptide Sequencing. Spectrum Graph . Protein Identification via Database Search. Identifying Post Translationally Modified Peptides . Spectral Convolution . Tommi Eronen. Max-Planck-Institut für Kernphysik. Heidelberg, Germany. Outline. Penning trap mass spectrometry. Q. = . m. parent. – . m. daughter. . Masses for CKM unitarity tests.... Superallowed beta decay. Andrew Rouff and Ben Berger. A Brief History. 1897- JJ Thomson recorded first mass-to-charge ratio of electrons. 1951- W. Pauli and H. Steinwedel developed first quadrupole mass spectrometer. 1959- K. Biemann applies electron ionisation mass spectrometry. Courtesy www.lab-initio.com. Purpose of Mass Spectrometry. P. roduces.  . spectra of masses from . the molecules . in . a sample of . material, and fragments of the molecules.. U. sed . to determine . Science Afternoon at NIST. February 4. th. , 2013. Questions Analytical (Bio)Chemists Ask. Environmental. Is the water safe to drink?. Deepwater. Horizon Oil Spill: Where did the oil go? When will the seafood be safe to eat again?. Introduction . to Spectroscopy. Spectroscopy involves an interaction between matter and light . (EMR). Light can be thought of as waves of energy or packets (particles) of energy called photons. Properties of light waves include wavelength and frequency. Know what information they can provide. Interpret simple mass spectra graphs. Know some uses of mass spectrometry. A mass spectrometer….. Draw the mass spectrometer. Describe the 5 step process. AS A CARTOON STORY BOARD!. Objectives of the presentation. To get an appreciation of the role of . physics . in . our day to day living. Acquaint ourselves to a novel and . widely used . research tool: Mass Spectrometer. To . introduce the basic physics of mass . ALONG WITH . H/D. EXCHANGE TO CHARACTERIZE . ANTIPLATELET DRUG DEGRADATION PATHWAYS.. A case report. .. B. ernard Do*, . Fatma . Amrani. , . Philippe-Henri . Secrétanand. . Najet. . Yagoubi. *Hospital Pharmacist . Peptide identification. CSE182. General isotope computation. Definition:. Let p. i,a. be the abundance of the isotope with mass i Da above the least mass. Ex: P. 0,C. : abundance of C-12, P. 2,O. : O-18 etc.. Mass Spectrometry deals with the examination of characteristics fragments and arising from the breakdown of organic molecules. The mass spectrum is the plot of relative intensity of the ions agains