PPT-Neuropathology & Genetics of Parkinsonism

Dennis W Dickson MD Department of Neuroscience Mayo Clinic Jacksonville FL Parkinsonism clinical syndrome Macroscopic findings in Parkinsonism Loss of neuromelanin pigmentation of substantia nigra dopaminergic neurons and locus ceruleus noradrenergic neurons. Julia . Kofler. and Kate McFadden. Outline. The CNS Autopsy. Dura removal. Spinal cord squeeze. Basic . Neuroanatomy. Gross Neuropathology. Bloody brain. The CNS Autopsy. Examination of the brain and spinal cord at autopsy is performed to diagnose diseases affecting the CNS and to correlate lesion type/ patterning with . for . Young Neurologists. Video Dinner. February 21, 2015. Maria Eliza T. . . Freitas, MD. Clinical Fellow In Movement Disorder. University of Toronto. Toronto Western Hospital. History. 40 year-old male, right-handed. Dr Jamie Farmer. Outline. Parkinsonism . vs. PD. Causes of parkinsonism. Akinetic. rigid syndromes. IPD. Signs/symptoms. Examination. Differential diagnosis. Investigations. Management. Complications. Parkinson’s Disease. Definition. Aetiology. PD . vs. Parkinsonism. Symptoms and signs. Differentials. Investigations. Management. Prognosis. 1. What is the definition of Parkinson’s disease?. 1. What is the definition of Parkinson’s disease?. Next Generation Technology . Developments and Applications:. Now and Potential across Healthcare. Eileen Roberts. Thalia Antoniadi. http://www.nbt.nhs.uk/genetics. The changing landscape . Advances in technology are altering the landscape of medical care . Information for patients and families . Christopher Stephen, MD, MRCP (UK). Nutan. Sharma, MD, PhD. X-Linked . Dystonia. -Parkinsonism (XDP). - What is it?. Multiple names. XDP. DYT3 by dystonia classification. Parkinsons-2015August 11-13, 2015August 11-13, 2015 Frankfurt, Germany International Conference on Page 30 Nigro-striatal DA neurons in the world of volume transmission and heteroreceptor complexes: some or all accepted cardinal signs 147rest148 tremor plastic rigidity delayed initiation movement slowness were recorded on all pa- initial symptoms and date death dura- family history ism or neurolo Julia . Kofler. and Kate McFadden. Outline. The CNS Autopsy. Dura removal. Spinal cord squeeze. Basic . Neuroanatomy. Gross Neuropathology. Bloody brain. The CNS Autopsy. Examination of the brain and spinal cord at autopsy is performed to diagnose diseases affecting the CNS and to correlate lesion type/ patterning with . Richard J Davenport . Edinburgh. The problem. 74 . yr. old male. Shakey. , mainly R hand. ?mother had a shake. Not much else. Is this parkinsonism?. If yes…..is it PD or something else?. If no……what is it?. Xiaowei Su, PGY-3 & Dr. Geoffrey Murdoch. Adapted from slides by . jen. . nichols. and . robyn. massa. Bacterial Meningitis. Meningitis is an inflammatory disease of the leptomeninges. Abnormal number of white blood cells in the CSF. �� Puschmann: Review monogenic PDthese genes and their frequency. Point mutations and multiplicationsin SNCAcause cognitive or psychiatric symptoms, parkinsonism, dysauto Jenny Kim. 1. , Dahima Cintron. 2. ,Catherine Groden. 1. , Edythe Wiggs. 1. , Joie Davis. 1. , Pramod Mistry. 3. , Gregory Pastores. 4. , Ari Zimran. 5. , Ozlem Goker-Alpan. 6. , Ellen Sidransky. 1. and Grisel Lopez. Advisory Board on Toxic Substances and Worker Health. Parkinson Disease Working Group. May 8-9, 2024. SEM . Health Effects: . Parkinsonism (Aliases) . April 12, 2024 . ABTSWH . Parkinson Disorders Recommendation .