PPT-Drug drug interactions highlighting P450 Cytochromes

Louis Wu PAC Presented at VAPAA Annual Meeting March 2 2017 Financial Disclosures and Conflicts I have no financial disclosures nor conflicts concerning this talk Learning Objectives. Suvash . Sedhain. , Scott . Sanner. , . Lexing. . Xie. , Riley Kidd, . Khoi. -Nguyen Tran, Peter Christen. Australian National University. NICTA. Like/Dislike?. Friends. Liked U’s Video. Justin . xenobiotic. . metabolism and . pharmacogenetics. George Howell III, . Ph.D. Sites of drug metabolism. Liver – responsible for the majority of drug metabolism. First pass metabolism. Kidney. GI. Lung. Presented by . Leticia Bonita Prince. Newcastle University 4. th. Year . MChem. Student. Aims of Today. Increase your understanding of intermolecular interactions. Increase your spatial skills and awareness using software designed by the CCDC. Cornell Notes and Q’s:. Take 2 pages of Cornell Notes based on the information you learn about in this presentation. . Answer the Questions you see included on the slides. (Q:). These notes will be included in a notebook check. 20 . By . Alysia. Glover and . Shanah. Roberts. 3. rd. Hr.. My Reading Standard. By the end of 9th grade , we should be able to read and comprehend nonfiction with 9th grade complexity proficiently.. Marking & Highlighting. By Lacey Buchanan. Presentation Overview. Research Paper (Thesis and facts). Physical Project . What was learned. The success I had. The challenges. Mentor information. Closing Statements. Research Paper. Jennifer N. Fosnot, Pharm.D.. Nurse Practitioners Symposium. Nashville, TN. September 27-28. th. , 2012. Objectives. 1.) Discuss the CYP 450 enzymes and common drug interactions with the immunosuppressants. A Guide to Aid Studying. How Not to Highlight. Not every word is important. Highlighting is not to just find the bold words and words around that bold word.. In Science, bold words are a guide but not the only thing you read in a selection. Alexandra Kent & Allyson Brome. University of Utah. Non Covalent Interactions. Wiki Page. : . http. ://en.wikipedia.org/wiki/Non-. covalent_interactions. . Other References: . Anslyn. , E. V., Dougherty, D. A. (2006). Modern Physical Organic Chemistry. Sausalito, CA. University Science.. Audry Kang. 7/15/2013. Central Dogma of Molecular Biology. Protein Review. Primary Structure: . Chain of amino acids. Secondary Structures: . Hydrogen bonds resulting in alpha helix, beta sheet and turns. T. ypes of wave interactions. Reflection. Refraction. Diffraction. Interference. Reflection. The bouncing back of a wave when it hits a surface.. * NOTE: When waves hits a substance some of it is transmitted and some of it is reflected.. June 12, 2018. Why PPI?. Protein-protein interactions determine outcome of most cellular processes. Proteins which are close homologues often interact in the same way. Protein-protein interactions place evolutionary constraints on protein sequence and structural divergence. . Department . of Pharmaceutics. 1. 26-Feb-16. Drug interactions . :. . These are said . to occur when the pharmacological activity of a drug is altered by the concomitant use of another drug or by the presence of some other substance. . . Ravikumar. Junior Resident . SVIMS, . Tirupathi. .. 1. Contents :. Introduction. Metabolism of . Xenobiotics. . Phase I reaction . Phase II reaction . Cytochrome. P450. Toxic effects to . xenobiotics.