PPT-Drug drug interactions highlighting P450 Cytochromes

Louis Wu PAC Presented at VAPAA Annual Meeting March 2 2017 Financial Disclosures and Conflicts I have no financial disclosures nor conflicts concerning this talk Learning Objectives. xenobiotic. . metabolism and . pharmacogenetics. George Howell III, . Ph.D. Sites of drug metabolism. Liver – responsible for the majority of drug metabolism. First pass metabolism. Kidney. GI. Lung. Duri. . Xixi. Hong. . Joseph . Lustig. Aleksandra . Porebska. . C-. Src. Kinase Inhibition: . A Promising Route in Kidney Cancer Treatment. Outline. Overview of c-. Src. Activation/VEGF pathway. Jennifer N. Fosnot, Pharm.D.. Nurse Practitioners Symposium. Nashville, TN. September 27-28. th. , 2012. Objectives. 1.) Discuss the CYP 450 enzymes and common drug interactions with the immunosuppressants. Phase I and II reactions . Xenobiotics . Foreign chemical substance . Can be absorbed across lungs, skin or ingested . Drugs are considered xenobiotics . Excreted in bile, urine, sweat, breath . Pharmacologically Active Compounds. Presented by:. Dr.Rania. Magadmi. The aim of this presentation is to highlight the clinicalinteractions between herbal product and prescribeddrugs. . . Mechanism of Drug- Herb interactions. Literature review. Dr Shaheen. Delivered By . Dr Naser . Drug interactions- objectives. Discuss Pharmacokinetic interactions. List . Pharmacodynamic. interactions. Comment . on common Drug- Food interactions. Drug interactions. . Department . of Pharmaceutics. 1. 26-Feb-16. Drug interactions . :. . These are said . to occur when the pharmacological activity of a drug is altered by the concomitant use of another drug or by the presence of some other substance. . Drug-Drug Interactions. Basic mechanisms of drug-drug interactions. Clinical significance of drug-drug interactions. Minimizing adverse drug-drug interactions. Drug-Drug Interactions. Interactions can occur whenever a patient takes more than one drug.. An Antiretroviral Therapy Review. Sarah Pérez, PharmD, PhC, BCACP, AAHIVP. Disclosure. The speaker has no actual or potential conflicts of interest in relation to this presentation. . Objectives. Pharmacists. 3rd Stage . College of Pharmacy . Al-. Mustansiriyah. University. Dr. . Basma. Al- . Sudani. Lecture . 5. 27-6-2021. BIOMEDICAL IMPORTANC. Xenobiotics. are a wide variety of foreign chemicals , both naturally occurring compounds in plant foods, and synthetic compounds in medicines, food additives, and environmental pollutants.. Travis R. . Goodwin. 1. , . Dina . Demner-Fushman. 1. , Kin Wah Fung. 1. , . and . Phong. Do. 2. 1. . Lister Hill National Center for Biomedical Communications, . U.S. National Library of Medicine. in . the Management of . HIV: . A Case-Based Discussion. Charles . W. Flexner. , MD. Professor . of Medicine, Pharmacology and Molecular Sciences, and International . Health. The Johns Hopkins University . Drug Drug Interaction Extraction from Product Labels . Bharath . Dandala. (. bdand@us.ibm.com. ). Diwakar Mahajan (. dmahaja@us.ibm.com. ). Ananya Poddar (. poddar@us.ibm.com. ). Introduction. Drug to drug interactions is the most common cause of adverse events, and preventable adverse events are the eighth leading cause of death in the United States.. Aman. Edited by Margaret Hilton. Honors Organic Chemistry. Chem. 2321 (. Sigman. ), 2013. Cytochrome P450 Oxidase. Overview. : . Cytochrome P450 Oxidases (CYPs) are the principal enzymes implicated in drug metabolism, catalyzing approximately 75% of reactions (1). The .