Gon çalo M Marques Jan Baas Starrlight Augustine and Jean Lou Dorne The job Tools for ERA based on DEB for individuals and populations single compounds ID: 622538
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Slide1
Modelling individual and population dynamics in application to risk assessment of chemical mixtures
Gon
çalo
M. Marques
Jan
Baas
,
Starrlight
Augustine
and
Jean-
Lou
Dorne
Slide2
The job:
Tools
for ERA
based on DEB forindividuals and populationssingle compounds and mixtures
Summary
in RSlide3
Summary
Literature review
Database
R code
individual model
R code
population modelSlide4
Literature review
Examples of keywords used:
• DEB
• Dynamic Energy Budget• Mixtures• Ecotoxicology• Modelling• Mortality• Growth• Reproduction• Population Dynamics• Individual based modellingSlide5
Literature review
Examples of keywords used:
• DEB
• Dynamic Energy Budget• Mixtures• Ecotoxicology• Modelling• Mortality• Growth• Reproduction• Population Dynamics• Individual based modellingT.
Jager
et al., Debkiss
or the quest for the simplest generic model of animal life history. Journal of Theoretical Biology, 328:9-18, 2013
K.
Lika
et al., The `covariation method' for estimating the parameters of the standard Dynamic Energy Budget model I: philosophy and approach. J. Sea Res., 66:270-277, 2011Slide6
Literature review
Examples of keywords used:
• DEB
• Dynamic Energy Budget• Mixtures• Ecotoxicology• Modelling• Mortality• Growth• Reproduction• Population Dynamics• Individual based modellingGeneral DEB
modelling
18
Effects
of mixtures
7
Population
dynamics
15
RefsSlide7
DEBSlide8
DEBecotox d
atabaseSlide9
DEBecotox database
par
conc
NEC
Slide10
DEB MoASlide11
DEB MoA
Assimilation
Maintenance
Growth
Reproduction
Surviva
lSlide12
DEB MoA
Assimilation
Maintenance
Growth
Reproduction
Surviva
lSlide13
Mixtures
Assimilation
Maintenance
Growth
Reproduction
Surviva
l
Independent
actionSlide14
Mixtures
Assimilation
Maintenance
Growth
Reproduction
Surviva
l
Similar
actionSlide15
Mixtures
Quantitative Structure Activity
Relationships (QSAR)
Body-size
scaling relationshipsSlide16
DEBecotox R package
Add-my-Pet
code structureSlide17
DEBecotox R packageSlide18
DEBecotox R packageSlide19
DEBecotox R package
Typified
model
DEB
MoA
Group
of actionSlide20
DEBecotox R package
Typified
model
DEB
MoA
Group
of
actionSlide21
DEBecotox R packageSlide22
Future developments
Literature review
Database
R code
individual model
R code
population modelSlide23
Thank
you
!EFSA, Nov 2015