PPT-The role of respiration in virulence gene expression of

Author : giovanna-bartolotta | Published Date : 2016-08-08

Vibrio cholerae HHMI 2011 Sara Fassio Dr Claudia H ä se Dr Yusuke Minato Cholera Infection of small intestine Causes severe diarrhea and electrolyte loss 35

Presentation Embed Code

Download Presentation

Download Presentation The PPT/PDF document "The role of respiration in virulence gen..." is the property of its rightful owner. Permission is granted to download and print the materials on this website for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.

The role of respiration in virulence gene expression of: Transcript

Vibrio cholerae HHMI 2011 Sara Fassio Dr Claudia H ä se Dr Yusuke Minato Cholera Infection of small intestine Causes severe diarrhea and electrolyte loss 35 million cases a year 100000 120000 deaths per year . Inducible gene expression. kinetics of . β-galactosidase. enzyme induction. Add inducer. start transcription = mRNA accumulation. mRNA translation = protein accumulation. Remove inducer. Stop. transcription (. The problem to be solved (an example). Hauf, J., Zimmermann, F.K., M. ü. ller, S., 2000. Simultaneous genomic over expression of seven glycolytic enzymes in the yeast Saccharomyces cerevisiae. Ezyme. Microbiol. Technol.. What does the operon model attempt to explain?. the coordinated control of gene expression . in bacteria. bacterial resistance to antibiotics. how genes move between homologous regions of DNA. the mechanism of viral attachment to a host cell. Adam Stevens, Daniel Hanson, Andrew . Whatmore. , Benoit . Destenaves. , Pierre . Chatelain. , Peter . Clayton. Supplementary Information: . Introduction. In this Supplementary Information we make available additional data that were discussed in the main manuscript. . . Differential . expression, clustering, networks, and functional enrichment. STEMREM 201 Fall 2012. Aaron . Newman, Ph.D.. 10/17/12. A . genomics approach . to . biology involves…. A plethora of . University of Notre Dame. Kristin Hager, Associate Teaching Professor, Biological Sciences. Joseph O’Tousa, Professor, Biological Sciences. WH Freeman. Marc Mazzoni, Senior Editor, Life Sciences. Elaine Palucki, Editor, Adjunct Assistant Professor Biology, Brooklyn College. TUMOR SUPRESSOR PROTEINS. ATP. ENZYMES THAT CONTROL CELLULAR RESPIRATION. ADAPTIVE GENE PRODUCTS ARE ONLY REQUIRED UNDER CERTAIN CONDITIONS. GENES FOR PROTEIN DIGESTION ARE TURNED OFF WHEN THERE IS NO PROTEIN AVAILABLE. . Saccharomyces . cerevisiae. using . GRNmap. K. Grace Johnson. 1. , Margaret J. O’Neil. 2. , . Kam. D. Dahlquist. 2. , and Ben G. Fitzpatrick. 3. 1. Department of Chemistry and Biochemistry, . 2. Department of Biology, . Post-transcriptional Modification of RNA: Effect on Biology and Virulence of . Salmonella. Salmonella. Pathogenesis. Hensel et al, 2001. tRNA. Modification Enzymes. tRNAs. are key molecules of translational machinery that ensure decoding of successive codons in mRNA inside the ribosome.. Gene Expression. Gene Expression. Transcription. Splicing. Polyadenylation. mRNA Stability. Translation. Protein Stability. Controls on Protein Levels. Transcription Control - Prokaryotic Promoter. Transcription Control - Prokaryotic Promoter. RNA can destabilize mRNA. Single-stranded RNA can affect gene expression. Double-stranded RNA can affect gene expression. All of above. . Before their study, it is known that. Single stranded RNA can cause RNA interference. Drosophila. Embryos using . lacZ. Transgenes. June 18. th. ABLE 2014. University of Oregon, Eugene. Cathy Silver Key. Julie Gates. Jessica Sawyer. Kirsten . Guss. Acknowledgements. Funding from . Roberta . We performed a genome-wide analysis of gene expressionto identify germline- and sex-regulated genes.Using mutants that cause defects in germ cell proliferationor gametogenesis, we identiÞed sets of g Pearley Chinta and Juliet V. Spencer . Abstract. Methods. Results. Conclusions. HCMV is a widespread pathogen in the general population and can cause severe disease in immune-compromised hosts. HCMV manipulates immune responses in several ways, one of which includes encoding genes with homology to host chemokine receptors. HCMV US27 encodes a chemokine-like receptor that stimulates host gene expression. While, no chemokine ligand has been identified for US27, it is constitutively active. US27 stimulates the gene expression of antioxidant response element (ARE) regulated genes by activation of the transcription factor nuclear respiratory factor 1 (NRF-1). The goal of this project is to identify specific host and viral genes that are regulated by US27. Increased expression of antioxidant genes is likely to benefit virus infection and enable more progeny virus to be produced. Thus, a better understanding of the US27 function has the potential to lead to the development of novel antiviral therapies necessary to treat HCMV infection. .

Download Document

Here is the link to download the presentation.
"The role of respiration in virulence gene expression of"The content belongs to its owner. You may download and print it for personal use, without modification, and keep all copyright notices. By downloading, you agree to these terms.