PPT-Deep Learning for Distinguishing Morphological Features of Acute Promyelocytic Leukemia

JohnWilliam Sidhom MDPhD Candidate 21 Department of Biomedical Engineering Johns Hopkins University School of Medicine Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University. trisenoxcompatientimages212image httpwwwtrisenoxcompatientimages212image ajpg ajpg APL Symptoms APL Symptoms Fatigue weakness shortness of breath Fatigue weakness shortness of breath From anemia low red blood cells From anemia low red blood cells Eas Adam Coates. Stanford University. (Visiting Scholar: Indiana University, Bloomington). What do we want ML to do?. Given image, predict complex high-level patterns:. Object recognition. Detection. Segmentation. Quoc V. Le. Stanford University and Google. Purely supervised. Quoc V. . Le. Almost abandoned between 2000-2006. - . Overfitting. , slow, many local minima, gradient vanishing. In 2006, Hinton, et. al. proposed RBMs to . Early Work. Why Deep Learning. Stacked Auto Encoders. Deep Belief Networks. CS 678 – Deep Learning. 1. Deep Learning Overview. Train networks with many layers (vs. shallow nets with just a couple of layers). English 252 . The Price of Survival. Acute Lymphocytic (ALL) Leukemia. in Children. cancer . of the white blood . cells . . -- . the . cells . in . the body that . normally . fight . infections. (“. Division of Diagnostic GenomicsLaboratory Test DirectoryPML/RARARNA expressionanalysisCPT Codes81315 81316Service Code IU Health 53053054Ordering RecommendationDiagnosis and monitoring of t1517 PML/R Manahil. . Ghandour. Definition :. . A group of malignant diseases characterized by uncontrolled proliferation of the precursors of white blood cells. .. Incidence :. . Leukemias. are the most common form of malignancy in childhood . Arif Ali Awan – R2 JGH. November 27. th. , 2014. IM Teaching. Disclaimer. Just a Resident. Case. 52F Nurse, 3 sisters. PMHx. : HTN, hysterectomy. Meds: . Hctz. 12.5; NKDA. No family history. Presents with 6 week history of intermittent fever (. Acute Promyelocytic Leukemia No. 26www.LLS.org • 800.955.4572 Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML) in which cells in the bone marrow that p 127. Takeshita A, Shinjo K, Naito K, Ohnishi K, Sugimoto Y, Yamakawa Y, Tanimoto M, Kitamura K, Naoe T, Ohno R. Role of P-glycoprotein in all-trans retinoic acid (ATRA) resistance in acute promyelocy 3 and maintain proliferate appropriately. Each of the involved cell lines may be affected to varying degrees. Patients with AML will present with disorders of infection (WBC), bleeding (RBC or pOateOe Introduction to Leukemia. Definition. Historic Perspective. Etiology and Risk Factors . Incidence. Classification. Comparison of Acute and Chronic Leukemia. Leukemia. Definition. Leukemia is a malignant disease of hematopoietic tissue characterized by the accumulation abnormal white cells (neoplastic or leukemic) in the bone marrow leading to bone marrow failure, a raised circulating white cell count (leukocytosis) and infiltrate organs (e.g liver, spleen, lymph nodes, brain) . Kelsey Shaffer. CHTN. Staff Meeting Presentation. What is it?. Acute Lymphoblastic Leukemia (ALL) is a blood cancer. White Blood Cells (WBC). Lymphocytes or Lymphoblast . Too many immature WBC. Crowd the bone marrow. . A. ccumulation of abnormal blasts (. I. mmature precursors of WBC). . in bone marrow and blood leading to:. . 1- Bone marrow failure. . (. anemia ,neutropenia & thrombocytopenia). . 2- Organ infiltration .