JBC Editorials Breast cancer the menacing face of Janus kinase C J Watson and K Hughes Cell Death Differ 21 185186 doi101038cdd2013170 The apoptotic pore on mitochondria are we breaking through or still stuck ID: 1046105
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21. EditorialsBreast cancer: the menacing face of Janus kinaseC J Watson and K HughesCell Death Differ 21: 185-186; doi:10.1038/cdd.2013.170The apoptotic pore on mitochondria: are we breaking through or still stuck?C Borner and D W AndrewsCell Death Differ 21: 187-191; doi:10.1038/cdd.2013.169PARP inhibitors and IR join forces to strike glioblastoma-initiating cellsN Lugli, I Kamileri and T D HalazonetisCell Death Differ 21: 192-193; doi:10.1038/cdd.2013.172Tumour-promoting role of EMT-inducing transcription factor ZEB1 in mantle cell lymphomaA E SayanCell Death Differ 21: 194-195; doi:10.1038/cdd.2013.178ReviewsBuilding blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis FREED Westphal, R M Kluck and G DewsonCell Death Differ 21: 196-205; advance online publication, October 25, 2013; doi:10.1038/cdd.2013.139The rheostat in the membrane: BCL-2 family proteins and apoptosis FREEN Volkmann, F M Marassi, D D Newmeyer and D HaneinCell Death Differ 21: 206-215; advance online publication, October 25, 2013; doi:10.1038/cdd.2013.153
22. Immunobiology of mesenchymal stem cells OpenS Ma, N Xie, W Li, B Yuan, Y Shi and Y WangCell Death Differ 21: 216-225; advance online publication, November 1, 2013; doi:10.1038/cdd.2013.158Role of caspase-8 in thymus functionN Pozzesi, A Fierabracci, A M Liberati, M P Martelli, E Ayroldi, C Riccardi and D V DelfinoCell Death Differ 21: 226-233; advance online publication, November 22, 2013; doi:10.1038/cdd.2013.166Original PapersDysregulated STAT1-SOCS1 control of JAK2 promotes mammary luminal progenitor cell survival and drives ERα+ tumorigenesisS R Chan, C G Rickert, W Vermi, K C F Sheehan, C Arthur, J A Allen, J M White, J Archambault, S Lonardi, T M McDevitt, D Bhattacharya, M V Lorenzi, D C Allred and R D SchreiberCell Death Differ 21: 234-246; advance online publication, September 13, 2013; doi:10.1038/cdd.2013.116The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphomaE Sánchez-Tilló, L Fanlo, L Siles, S Montes-Moreno, A Moros, G Chiva-Blanch, R Estruch, A Martinez, D Colomer, B Győrffy, G Roué and A PostigoCell Death Differ 21: 247-257; advance online publication, September 6, 2013; doi:10.1038/cdd.2013.123
23. Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells FREEM Venere, P Hamerlik, Q Wu, R D Rasmussen, L A Song, A Vasanji, N Tenley, W A Flavahan, A B Hjelmeland, J Bartek and J N RichCell Death Differ 21: 258-269; advance online publication, October 11, 2013; doi:10.1038/cdd.2013.136Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degenerationY Murakami, H Matsumoto, M Roh, A Giani, K Kataoka, Y Morizane, M Kayama, A Thanos, S Nakatake, S Notomi, T Hisatomi, Y Ikeda, T Ishibashi, K M Connor, J W Miller and D G VavvasCell Death Differ 21: 270-277; advance online publication, August 16, 2013; doi:10.1038/cdd.2013.109Perturbation of Hoxb5 signaling in vagal and trunk neural crest cells causes apoptosis and neurocristopathies in miceM K M Kam, M C H Cheung, J J Zhu, W W C Cheng, E W Y Sat, P K H Tam and V C H LuiCell Death Differ 21: 278-289; advance online publication, October 18, 2013; doi:10.1038/cdd.2013.142Transcriptional fine-tuning of microRNA-223 levels directs lineage choice of human hematopoietic progenitorsL Vian, M Di Carlo, E Pelosi, F Fazi, S Santoro, A M Cerio, A Boe, V Rotilio, M Billi, S Racanicchi, U Testa, F Grignani and C NerviCell Death Differ 21: 290-301; advance online publication, October 18, 2013; doi:10.1038/cdd.2013.145
24. miR-661 downregulates both Mdm2 and Mdm4 to activate p53Y Hoffman, D R Bublik, Y Pilpel and M OrenCell Death Differ 21: 302-309; advance online publication, October 18, 2013; doi:10.1038/cdd.2013.146Epidermal Snail expression drives skin cancer initiation and progression through enhanced cytoprotection, epidermal stem/progenitor cell expansion and enhanced metastatic potentialB De Craene, G Denecker, P Vermassen, J Taminau, C Mauch, A Derore, J Jonkers, E Fuchs and G BerxCell Death Differ 21: 310-320; advance online publication, October 25, 2013; doi:10.1038/cdd.2013.148Prolyl isomerase Pin1 and protein kinase HIPK2 cooperate to promote cortical neurogenesis by suppressing Groucho/TLE:Hes1-mediated inhibition of neuronal differentiationR Ciarapica, L Methot, Y Tang, R Lo, R Dali, M Buscarlet, F Locatelli, G del Sal, R Rota and S StifaniCell Death Differ 21: 321-332; advance online publication, November 22, 2013; doi:10.1038/cdd.2013.160Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesisA Macià, M Vaquero, M Gou-Fàbregas, E Castelblanco, J M Valdivielso, C Anerillas, D Mauricio, X Matias-Guiu, J Ribera and M EncinasCell Death Differ 21: 333-343; advance online publication, November 22, 2013; doi:10.1038/cdd.2013.161
25. Cell Death and Differentiation (2014) 21, 270–277; doi:10.1038/cdd.2013.109; published online 16 August 2013Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degenerationY Murakami1,2, H Matsumoto1, M Roh1, A Giani1, K Kataoka1, Y Morizane1, M Kayama1, A Thanos1, S Nakatake2, S Notomi2, T Hisatomi2, Y Ikeda2, T Ishibashi2, K M Connor1, J W Miller1 and D G Vavvas1AbstractThere is no known treatment for the dry form of an age-related macular degeneration (AMD). Cell death and inflammation are important biological processes thought to have central role in AMD. Here we show that receptor-interacting protein (RIP) kinase mediates necrosis and enhances inflammation in a mouse model of retinal degeneration induced by dsRNA, a component of drusen in AMD. In contrast to photoreceptor-induced apoptosis, subretinal injection of the dsRNA analog poly(I : C) caused necrosis of the retinal pigment epithelium (RPE), as well as macrophage infiltration into the outer retinas. In Rip3−/− mice, both necrosis and inflammation were prevented, providing substantial protection against poly(I : C)-induced retinal degeneration. Moreover, after poly(I : C) injection, Rip3−/− mice displayed decreased levels of pro-inflammatory cytokines (such as TNF-α and IL-6) in the retina, and attenuated intravitreal release of high-mobility group box-1 (HMGB1), a major damage-associated molecular pattern (DAMP). In vitro, poly(I : C)-induced necrosis were inhibited in Rip3-deficient RPE cells, which in turn suppressed HMGB1 release and dampened TNF-α and IL-6 induction evoked by necrotic supernatants. On the other hand, Rip3 deficiency did not modulate directly TNF-α and IL-6 production after poly(I : C) stimulation in RPE cells or macrophages. Therefore, programmed necrosis is crucial in dsRNA-induced retinal degeneration and may promote inflammation by regulating the release of intracellular DAMPs, suggesting novel therapeutic targets for diseases such as AMD.
26. PreviewsConcerted Effort: Oscillations in Global Gene Expression during Nematode Development Sunil Laxman, Benjamin P. Tu, Steven L. McKnightBack to Bases: How a Nucleotide Biosynthetic Enzyme Controls p53 Activation Anna L. Guarnieri, Joaquín M. EspinosaArticlesNitric Oxide Sensing in Plants Is Mediated by Proteolytic Control of Group VII ERF Transcription FactorsDaniel J. Gibbs, Nurulhikma Md Isa, Mahsa Movahedi, Jorge Lozano-Juste, Guillermina M. Mendiondo, Sophie Berckhan, Nora Marín-de la Rosa, Jorge Vicente Conde, Cristina Sousa Correia, Simon P. Pearce, George W. Bassel, Bulut Hamali, Prabhavathi Talloji, Daniel F.A. Tomé, Alberto Coego, Jim Beynon, David Alabadí, Andreas Bachmair, José León, Julie E. Gray, Frederica L. Theodoulou, Michael J. HoldsworthExtensive Oscillatory Gene Expression during C. elegans Larval Development Gert-Jan Hendriks, Dimos Gaidatzis, Florian Aeschimann, Helge GroßhansLong Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune StimuliKatsutoshi Imamura, Naoto Imamachi, Gen Akizuki, Michiko Kumakura, Atsushi Kawaguchi, Kyosuke Nagata, Akihisa Kato, Yasushi Kawaguchi, Hiroki Sato, Misako Yoneda, Chieko Kai, Tetsushi Yada, Yutaka Suzuki, Toshimichi Yamada, Takeaki Ozawa, Kiyomi Kaneki, Tsuyoshi Inoue, Mika Kobayashi, Tatsuhiko Kodama, Youichiro Wada, Kazuhisa Sekimizu, Nobuyoshi Akimitsu
27. RIG-I Modulates Src-Mediated AKT Activation to Restrain Leukemic StemnessXian-Yang Li, Lin-Jia Jiang, Lei Chen, Meng-Lei Ding, He-Zhou Guo, Wu Zhang, Hong-Xin Zhang, Xiao-Dan Ma, Xiang-Zhen Liu, Xiao-Dong Xi, Sai-Juan Chen, Zhu Chen, Jiang ZhuRad54 Functions as a Heteroduplex DNA Pump Modulated by Its DNA Substrates and Rad51 during D Loop FormationWilliam Douglass Wright, Wolf-Dietrich HeyerThe Intrinsically Disordered Sem1 Protein Functions as a Molecular Tether during Proteasome Lid Biogenesis Robert J. Tomko, Mark HochstrasserMultivesicular GSK3 Sequestration upon Wnt Signaling Is Controlled by p120-Catenin/Cadherin Interaction with LRP5/6Meritxell Vinyoles, Beatriz Del Valle-Pérez, Josué Curto, Rosa Viñas-Castells, Lorena Alba-Castellón, Antonio García de Herreros, Mireia DuñachNucleotide Biosynthetic Enzyme GMP Synthase Is a TRIM21-Controlled Relay of p53 StabilizationAshok Reddy, Jan A. van der Knaap, Alice G.M. Bot, Adone Mohd-Sarip, Dick H.W. Dekkers, Mieke A. Timmermans, John W.M. Martens, Jeroen A.A. Demmers, C. Peter VerrijzerEarly Steps in Autophagy Depend on Direct Phosphorylation of Atg9 by the Atg1 KinaseDaniel Papinski, Martina Schuschnig, Wolfgang Reiter, Larissa Wilhelm, Christopher A. Barnes, Alessio Maiolica, Isabella Hansmann, Thaddaeus Pfaffenwimmer, Monika Kijanska, Ingrid Stoffel, Sung Sik Lee, Andrea Brezovich, Jane Hua Lou, Benjamin E. Turk, Ruedi Aebersold, Gustav Ammerer, Matthias Peter, Claudine KraftArginine Methylation Facilitates the Recruitment of TOP3B to Chromatin to Prevent R Loop AccumulationYanzhong Yang, Kevin M. McBride, Sean Hensley, Yue Lu, Frederic Chedin, Mark T. Bedford