PPT-Non-Antibody Mediated TRALI

Kevin Jenkins MD MBA MHSA Vanderbilt University Medical Center 121014 Overview What is TRALI Clinical presentation Prognosis Differential Diagnosis Standard therapy Traditionally accepted mechanism direct antibody mediated. immunology. What is hypersensitivity?. the violent reaction of the immune system leading to severe symptoms and even death in . sensitised. animal when it is re-exposed to the same antigen for the second time. It is nothing but allergy.. transfusion. BRI BUDLOVSKY R3. January 2015. OVERVIEW. The process. Blood components. Testing. Consent. Transfusion reactions. Donation. Donation. TEST. SPECIFIC. AGENTS. TESTS. Group. ABO,. Rh. Alloantibodies. . Localized and Systemic Anaphylaxis. Updated: November . 29, . 2016. Folder Title: . IgEAllerNoTP. Chapter 15, 7. th. Edition,. . Kuby. Immunology, pp 485 to 516. Immunology and Medicine. (See Presentation Called “. . Response occurs within days of the infection. . Highly specific. . Highly diverse. . Memory component. . Major cell types involved: T cells, B cells and antigen presenting cells. Antigens and Antibodies (CH4). Vaccine Research Center. National Institute of Allergy and Infectious Diseases. National Institutes of Health. Richard A. Koup, MD. July 19, 2014. CD8 T cells in germinal centers are functionally capable of mediating . Hypersensitivity. Autoimmunity. . Immunodeficiency . . • . Primary. • . Secondary . Hypersensitivity . In . hypersensitivity. , the . antigens . are not . destructive. , but the responses to them cause . Shejal Patel DO. Case 1. Mr. X is a 60 year old male with no past medical history and comes into the ER with complaints of fatigue and shortness of breath x 5 days. He takes no medications. He is noted on exam to be jaundiced and . Haney A. Mallemat, MD. Department of Critical Care. Dartmouth-Hitchcock Medical Center. Clinical Case. 77 M. AAA repair. POD #3. Extubated. Stable vitals. Hb. 8.1. Evening Vascular Rounds…. 2U PRBC. 1. Transport fluids = excess . interstitial fluids . are returned. to the cardiovascular system. 2. Immunity = houses and transports . lymphocytes. 3. Transport lipids = circulates fats, like vitamins . Importance of HLA in solid organ transplantation. Overview of HLA typing and histocompatibility testing in solid organ transplantation. HLA testing in solid organ transplantation. Dr. Robert Liwski, MD, PhD, FRCPC. HUMORAL IMMUNE SYSTEM BY: DR. LUNA PHUKAN TDC 5 TH SEM MAJOR : PAPER 5.3 CELL MEDIATED IMMUNE SYSTEM Cell - mediated immune responses involve the destruction of infected cells by cytotoxic T cell ACTIVE vs ADVANTAGES AND DISADVANTAGES OF EACH APPROACH Arturo Casadevall Albert Einstein College of Medicine Bronx, New York DEFINITIONS • ACTIVE IMMUNIZATION = VACCINES • PASSIVE IMMUNIZATION = -Was first termed . anaphylaxis. -can be systematic, which often leads to shock and can be fatal, or localized, which is various atopic reactions . Types of Reactions. There are four types of reactions. Dr. . Amany. . Ballow. . Consultant Immunology . Assistant professor KKUH. General Lab Director MDLAB. PhD, Diploma BSHI,MSC.. Objectives . To describe B-cells as the mediators of humoral immunity, (antibody-mediated immunity).