PPT-Non-Antibody Mediated TRALI

Kevin Jenkins MD MBA MHSA Vanderbilt University Medical Center 121014 Overview What is TRALI Clinical presentation Prognosis Differential Diagnosis Standard therapy Traditionally accepted mechanism direct antibody mediated. The immune mediated form can lead to thrombo sis and the need to consider alternative therapies Types of hepari n related thrombocytopenia HAT Non immune Mediated HIT Immune Mediated Frequency 10 30 1 3 Timing of Onset 4 days Typical 5 10 days Acute transfusion. BRI BUDLOVSKY R3. January 2015. OVERVIEW. The process. Blood components. Testing. Consent. Transfusion reactions. Donation. Donation. TEST. SPECIFIC. AGENTS. TESTS. Group. ABO,. Rh. Alloantibodies. . Localized and Systemic Anaphylaxis. Updated: November . 29, . 2016. Folder Title: . IgEAllerNoTP. Chapter 15, 7. th. Edition,. . Kuby. Immunology, pp 485 to 516. Immunology and Medicine. (See Presentation Called “. Monoclonal Antibody Production. Method. Monoclonal Antibody Production technology was developed in 1975. Since its development it has been very important in the modern medical science with the diagnosis, therapy, research and even basic science today. It is still largely dependent upon animal testing however. Because it requires immunization of mice in order for them to create the antibodies to be grown. . reactions. Let’s start. The immune system is a system of biological structures and processes within an organism that protects against disease.. . To function properly, an immune system must detect a wide variety of agents, from viruses to parasitic worms, and distinguish them from the organism’s own healthy tissue. . . Response occurs within days of the infection. . Highly specific. . Highly diverse. . Memory component. . Major cell types involved: T cells, B cells and antigen presenting cells. Antigens and Antibodies (CH4). Product Data Sheet Source of Antigen E coli Cat No Host Rabbit RD181239100 01 mgOther names PHBPreparation The antibody was raised in rabbits by immunization with the recombinant Human Prohibitin Amin Dr. Suzan Y.. Antigen. :. It s a substance that may be specifically bound by an antibody (. Ab. ) molecule or T cell receptors (TCR). When this binding lead to the activation of B cells or T cells ,this substance is known as . Daniel Patton. 1. , Natalie Stahr. 1. , . Payal. Agarwal. 1, 2. , and Bruce Smith. 1,2. 1. Scott Ritchey Research Center, College of Veterinary Medicine, Auburn University. 2. Department of Pathobiology, College of Veterinary Medicine, Auburn University. Richard . M. undembe. Focus of the presentation. The talk will focus on methods of plant transformation that have been used on non-model crops. . Cowpea, cassava, sweet potato and banana will be used as the main examples.. 6 One major challenge many areas are facing lack of clinician information. Many simply do not know where monoclonal antibody therapy is available, what the inclusion criteria are for patients, and ho HUMORAL IMMUNE SYSTEM BY: DR. LUNA PHUKAN TDC 5 TH SEM MAJOR : PAPER 5.3 CELL MEDIATED IMMUNE SYSTEM Cell - mediated immune responses involve the destruction of infected cells by cytotoxic T cell ACTIVE vs ADVANTAGES AND DISADVANTAGES OF EACH APPROACH Arturo Casadevall Albert Einstein College of Medicine Bronx, New York DEFINITIONS • ACTIVE IMMUNIZATION = VACCINES • PASSIVE IMMUNIZATION = Dr. . Amany. . Ballow. . Consultant Immunology . Assistant professor KKUH. General Lab Director MDLAB. PhD, Diploma BSHI,MSC.. Objectives . To describe B-cells as the mediators of humoral immunity, (antibody-mediated immunity).