Abstract Collagenous fibroma desmoplastic fibroblastomais a benign - PDF document

Abstract. Collagenous fibroma (desmoplastic fibroblastoma)is a benign fibrous soft tissue tumor that usually occurs inthe subcutaneous tissue or skeletal muscle of adults.Recent cytogenetic studies have revealed clonalrearrangements of the chromosomal band 11q12. Wepresent a unique case of collagenous fibroma arising in theright shoulder of a 63-year-old female. Magneticresonance imaging showed a solid soft tissue mass deeply 3259 Correspondence to:Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Collagenous Fibroma (Desmoplastic Fibroblastoma) with Trisomy 8 as the Sole Cytogenetic Abnormality, HIROSHI IWASAKI, SHINTARO YANO 0250-7005/2013 $2.00+.40 An open biopsy was performed, and the tumor washistologically diagnosed as a collagenous fibroma. Amarginal excision of the tumor was carried out.Microscopically, the excised tumor was composed ofscattered spindled and stellate-shaped cells in an abundantmitotic figures were observed.Conventional cytogenetic analysis revealed the followingwing()The postoperative course was uneventful, and the patientis doing well without local recurrence two months after thesurgery.Discussionrearrangement is characteristic of collagenous fibroma, withidentified in a case of fibroma of tendon sheath (13).Recently, Macchia outcome of 11q12 rearrangement is a deregulated expressionFOS-like antigen-1) in collagenous fibroma. Inthe present study, we recorded the occurrence of trisomy 8the primary anomaly may not be recognizable. To the best ofour knowledge, this is the first reported case of isolatedtrisomy 8 in collagenous fibroma.Trisomy 8 is a non-random aberration in a subgroup ofbenign fibrous lesions (14). Notably, this numericalchromosomal aberration has been detected at the cytogeneticor molecular cytogenetic level in a significant subset ofdesmoid-type fibromatoses (14-19), with a similarhistological appearance to collagenous fibroma. Thesefindings suggest that trisomy 8 may contribute to aberrantcell prolifera

tion in primary fibrous lesions. On the otherabnormality in a variety of mesenchymal neoplasms, such asEwings sarcoma (22).The differential diagnosis of collagenous fibroma includesas fibroma of tendon sheath, tenosynovial giant cell tumor,solitary fibrous tumor, and desmoid-type fibromatosis. Thesetumors can exhibit similar signals on T1- and T2-weightedsequences. The most significant differential diagnosis to beconsidered is desmoid-type fibromatosis, as in our case.Recently, Yamamoto of rim enhancement on contrast-enhanced fat-suppressed T1-collagenous fibroma. In the present case, we observed asimilar enhancement pattern at the periphery of the lesion.On the other hand, desmoid-type fibromatosis would not beas clearly circumscribed as collagenous fibroma andtypically exhibits moderate-to-marked enhancement.Prominent low-signal intensity band on all pulse sequencescan be seen in desmoid-type fibromatosis (24). The enhancedpattern and the presence of low-signal intensity band may beuseful to distinguish between collagenous fibroma anddesmoid-type fibromatosis.In summary, we have reported the first case of collagenousfibroma involving trisomy 8. Further studies are needed tofibroma. 3260 Axial magnetic resonance images of collagenous fibroma involving the right shoulder. A: T1-weighted sequence shows that the maslow-to-intermediate signal intensity. B: T2-weighted sequence shows that the mass has low-to-slightly high signal intensity. C: Contrast-enhancedfat-suppressed T1-weighted sequence shows heterogenous internal enhancement with rim enhancement. : Collagenous Fibroma with Trisomy 8 3261 Histological finding of collagenous fibroma. The tumor is hypocellular and consists of spindled and stellate-shaped cells in a collagenous stroma (hematoxylin and eosin staining, original magnification ×80). A representative Giemsa-Trypsin-Giemsa (GTG)-banded karyotype of collagenous fibroma showing trisomy 8 as the sole anomaly. AcknowledgementsThis work was supported in

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