PPT-Disorders of Growth Hormone

Practical Endocrinology Wendy Blount DVM The Pituitary Gland Two parts Adenohypophysis anterior lobe Pars distalis Pars intermedia Pars infundibularis Neurohypophysis posterior lobe Growth Hormone GH Somatotropin. Somatotropin effects in children and adolescents:. Stimulation of protein synthesis. Inhibition of protein breakdown . . Stimulation of rate of increase of cell size and . . Extension of long bones (arms and legs). & Pituitary Gland. Hypothalamus . and . Pituitary Gland. The hypothalamus and pituitary gland form a unit that exerts control over the function of several endocrine glands (thyroid, adrenals, and gonads), as well as a wide range of physiologic activities . Most children evaluated for short stature are . normal stature variants. .. The slow growth patterns of these children reflect familial short stature and/or constitutional delay of growth and puberty. Objectives. Define hormone action. Explain the 5 types of hormone action. Know the function and effects of hormones in detail. Hormone Action. Definition. Chemical messengers secreted by various tissues, not necessarily secreted by ductless glands.. Growth of an individual or an . organ involves:. Increase . both in cell number and . cell size. Differentiation . of cells to perform highly . specialized functions. and . tissue remodeling that . may . Objectives. Define hormone action. Explain the 5 types of hormone action. Know the function and effects of hormones in detail. Hormone Action. Definition. Chemical messengers secreted by various tissues, not necessarily secreted by ductless glands.. Danielle Compton. Production Location . Anterior lobe of the Pituitary gland. Target Cells. Affects all cells of the body. Production. Hypothalamus releases Human Growth Releasing Hormone stimulating the pituitary gland to release the HGH.. Practical Endocrinology. Wendy Blount, DVM. The Pituitary Gland. Two parts. Adenohypophysis – anterior lobe. Pars distalis. Pars intermedia. Pars infundibularis. Neurohypophysis - posterior lobe. Growth Hormone (GH) = Somatotropin. Acromegaly. -. Enlargement of bones of hands, feet, & jaw. - Results from increased secretion of . . somatotropic hormone. - usually caused by pituitary tumor. - Symptoms: headache & lethargy. somatotropin. ) size 191 amino acids mol wt. 22125 . kd. is secreted by Anterior Pituitary . Growth . hormone stimulates production of insulin-like growth factor 1. . Insulin-like . growth factor 1 . Policy: Medical Policy No. 30 .10.00 - 1 Last Updated 08 / 16 /2017 1 Growth Hormone Agents Medical p olicy n o. 30 . 10 . 00 - 1 Effective Date: July 1, 2018 Background: Human growth hormone, a  Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society. J . Clin. . GHRH. SRIF. Ghrelin. Pituitary. +. +. –. Roelfsema V, et al. . J Am Soc Nephrol.. 2001.. –. –. –. +. IGFBP-1. IGFBP-2. IGFBP-3. IGFBP-4. IGFBP-5. IGFBP-6. Free. IGF-I. +.  GFR. IGF-I. IGF-I. General principles of endocrine diagnosis . 116 . Disorders of posterior pituitary hormone secretion . 123 . Hypothalamus and pituitary gland . 116 . Hypopituitarism . 123 . Disorders of anterior pituitary hormone secretion .