PPT-HORMONE ACTION AND SIGNAL TRANSDUCTION

DR AMINA TARIQ BIOCHEMISTRY Survival of a multicellular organism depends on their ability to adapt to the constantly changing environment Intercellular communication mechanisms are necessary for this adaptation. Chapter 13, . Stryer. Short Course. Signal Transduction. Signal from exterior of cell must affect interior of cell. Through the membrane. Amplification of signal. Ability to turn off. A few pathways…. VOCABULARY. directions: mark each term to indicate if you know it, are unsure, or don’t.. amplify . communication. deleterious elaborate. embryology evolution . fluid . mosaic model mechanism. By. Dr. Ahmed . Hussain. A. . Mujamammi. . Clinical Chemistry Unit. Pathology Department. College of Medicine, KSU. OBJECTIVES. By the end of this lecture, students should be able to:. Acquire the knowledge for general consequence of hormone-receptor interaction . Pratt & . Cornely. , Chapter 10. Terms for Signal Transduction. Ligand. Receptor. Transducer. Effector. Second messenger. Target proteins/DNA. Ligands. Hormones vs Local mediators. Polar (insulin) vs nonpolar (steroidal hormone). . Signal Transduction Pathway. EXTRACELLULAR. FLUID. Plasma membrane. CYTOPLASM. Receptor. Signaling. molecule: ligand. Relay molecules in a signal transduction pathway. Activation. Pratt & . Cornely. , Chapter 10. Terms for Signal Transduction. Ligand (first messenger). Receptor (transducer). Primary Effector. Second . messenger. Second effector, etc.. Target proteins/DNA. Ligands. Signal transduction . General features of signal transduction. Type of cell signalling. Type of Signal . transducer/Receptors. signal transduction. T. he . signal. . represents the information, . that is detected by specific . Believed to have evolved in prokaryotes and single-celled eukaryotes. Single-celled organisms. Bacteria use communication in quorum sensing. Short distance communication using local regulators. Secrete . Dr . Amena. . Rahim. Biochemistry. Biomedical Importance. Intercellular communication mechanisms are necessary requirements for this adaptation. . The nervous system and the endocrine system provide this intercellular, organism-wide communication. . Dr. Kevin Ahern. EGFR Signaling, Part 1. Epidermal Growth Factor Receptor (EGFR). EGFR Dimer. Autophosphorylated. Tyrosines in . Cytoplasmic Domain. Signaling Complex. Assembled on . Phosphotyrosines. More than 4 years experience in developing and analyzing mathematical models of complex bio-chemical reaction networks 10 Journal papers, 1 book chapter, 6 peer-reviewed conference papers, and 7 Learning Objectives. Learn the general structure and properties of hormones.. Know the differences between Hormones, Neurotransmitters & enzymes. 3. . Understand . the general properties of signaling molecules (ligands), cell-surface receptors, & intracellular signal transduction components.. Cellular Signaling. Autocrine Signals . Diffuse from one part of a cell to another part of the same cell. Synaptic signaling. Neurotransmitter is the signaling molecule. Occurs in the animal nervous system. Alzayadneh. , PhD. Integrative Physiology and Pharmacology. 1. Introduction to Physiology (0501110) Spring 2013. Subject. Lecture No.. Lecturer. Pages in the 11. th. edition. textbook. Pages in the 12.