PPT-Cell Signaling Signal Transduction Pathways

Cellular Signaling Autocrine Signals Diffuse from one part of a cell to another part of the same cell Synaptic signaling Neurotransmitter is the signaling molecule Occurs in the animal nervous system. (from Kimura, 1966). Electron micrograph of 3 OHCs. spiral ligament. modiolus. When the basilar membrane vibrates up and down in response to the sound wave, the hair cell cilia are displaced 1. st. in one direction then in the other; i.e., 1. Greg, Lauren, Nancy, Mark, Gene. Facilitator: Paula. Level. Introductory biology. Knowledge of students prior to unit. Cell theory. Characteristics of life. Homeostasis . Chemistry of macromolecules. Chapter 13, . Stryer. Short Course. Signal Transduction. Signal from exterior of cell must affect interior of cell. Through the membrane. Amplification of signal. Ability to turn off. A few pathways…. . Signal Transduction Pathway. EXTRACELLULAR. FLUID. Plasma membrane. CYTOPLASM. Receptor. Signaling. molecule: ligand. Relay molecules in a signal transduction pathway. Activation. Cell-to-cell . signaling. : . Important . to both multicellular . & unicellular . organisms. . H. elps coordinate activities & . events necessary for . multicellular . organism to develop from . Dr. Kevin Ahern. EGFR Signaling, Part 1. Epidermal Growth Factor Receptor (EGFR). EGFR Dimer. Autophosphorylated. Tyrosines in . Cytoplasmic Domain. Signaling Complex. Assembled on . Phosphotyrosines. LO 3.36: The student is able to describe a model that expresses the key elements of signal transduction pathways by which a signal is converted to a cellular response. SP 1.5: The student can re-express key elements of natural phenomena across multiple representations in the domain. More than 4 years experience in developing and analyzing mathematical models of complex bio-chemical reaction networks 10 Journal papers, 1 book chapter, 6 peer-reviewed conference papers, and 7 Introduction. Cell signaling: . a biological mechanism that occurs in cells which gives cells an ability to receive or generate the signals in response to their surrounding environment.. Cell to cell communication . Discovery. Linkage data from transduction. Specialized transduction. Lytic and Lysogenic Cycle. Introduction. Transduction is the process by which DNA. . is transferred from one bacterium to another by a virus.. Van Delden C, Iglewski BH. Cell-to-Cell Signaling and Pseudomonas aeruginosa Infections. Emerg Infect Dis. 1998;4(4):551-560. https://doi.org/10.3201/eid0404.980405. Alzayadneh. , PhD. Integrative Physiology and Pharmacology. 1. Introduction to Physiology (0501110) Spring 2013. Subject. Lecture No.. Lecturer. Pages in the 11. th. edition. textbook. Pages in the 12. Outline. Review of Photosynthesis. Finish up Cam plants . Cell-Cell Communication. Local vs Long distance. Three Stages of Signaling. Reception. Transduction. Response. Photosynthesis - Overview. “Fixing” Carbon. PowerPoint Image Slideshow. This work is licensed under a . Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. .. Communication. As with people, it is vital for individual cells to be able to interact with their environment. In order to properly respond to externals stimuli, cells have developed complex mechanisms of communication that can receive a message, transfer the information across the plasma membrane, and produce changes within the cell in response to the message. The ability of cells to communicate through chemical signals originated in single cells and was essential for the evolution of multicellular organisms. (credit: modification of work by Vincent and Bella Productions).