PPT-Cell Signaling Signal Transduction Pathways

Cellular Signaling Autocrine Signals Diffuse from one part of a cell to another part of the same cell Synaptic signaling Neurotransmitter is the signaling molecule Occurs in the animal nervous system. Chapter 13, . Stryer. Short Course. Signal Transduction. Signal from exterior of cell must affect interior of cell. Through the membrane. Amplification of signal. Ability to turn off. A few pathways…. VOCABULARY. directions: mark each term to indicate if you know it, are unsure, or don’t.. amplify . communication. deleterious elaborate. embryology evolution . fluid . mosaic model mechanism. Pratt & . Cornely. , Chapter 10. Terms for Signal Transduction. Ligand. Receptor. Transducer. Effector. Second messenger. Target proteins/DNA. Ligands. Hormones vs Local mediators. Polar (insulin) vs nonpolar (steroidal hormone). . Signal Transduction Pathway. EXTRACELLULAR. FLUID. Plasma membrane. CYTOPLASM. Receptor. Signaling. molecule: ligand. Relay molecules in a signal transduction pathway. Activation. Pratt & . Cornely. , Chapter 10. Terms for Signal Transduction. Ligand (first messenger). Receptor (transducer). Primary Effector. Second . messenger. Second effector, etc.. Target proteins/DNA. Ligands. . Enzyme-linked . receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. Cell-to-cell . signaling. : . Important . to both multicellular . & unicellular . organisms. . H. elps coordinate activities & . events necessary for . multicellular . organism to develop from . Believed to have evolved in prokaryotes and single-celled eukaryotes. Single-celled organisms. Bacteria use communication in quorum sensing. Short distance communication using local regulators. Secrete . Kuby Immunology. , . 7e: Chapter 3. Essential Concepts – 1. A cellular signal is any event that instructs a cell to change its metabolic or proliferative state. Signals are usually generated by the binding of a ligand to a complementary cell-bound receptor. Dr. Kevin Ahern. EGFR Signaling, Part 1. Epidermal Growth Factor Receptor (EGFR). EGFR Dimer. Autophosphorylated. Tyrosines in . Cytoplasmic Domain. Signaling Complex. Assembled on . Phosphotyrosines. LO 3.36: The student is able to describe a model that expresses the key elements of signal transduction pathways by which a signal is converted to a cellular response. SP 1.5: The student can re-express key elements of natural phenomena across multiple representations in the domain. AND . MOTILITY (BIOL 3373) . WHAT IS The CELL SIGNALING?. 2. How cells receive and respond to signals from their surroundings. On one hand, cell signaling regulates gene expression and controls the cell fate (proliferation, motility, differentiation and programmed cell death, or apoptosis).. General Steps. 1. Receptor activation by extracellular/ intracellular signal. . 2. Binding of adapter proteins to receptor domains. 3. Recruitment of other proteins. 4. Phosphorylation, Ubiquitination, Acetylation etc.. Outline. Review of Photosynthesis. Finish up Cam plants . Cell-Cell Communication. Local vs Long distance. Three Stages of Signaling. Reception. Transduction. Response. Photosynthesis - Overview. “Fixing” Carbon.