PPT-Hormones and Signal Transduction III

Dr Kevin Ahern EGFR Signaling Part 1 Epidermal Growth Factor Receptor EGFR EGFR Dimer Autophosphorylated Tyrosines in Cytoplasmic Domain Signaling Complex Assembled on Phosphotyrosines. (from Kimura, 1966). Electron micrograph of 3 OHCs. spiral ligament. modiolus. When the basilar membrane vibrates up and down in response to the sound wave, the hair cell cilia are displaced 1. st. in one direction then in the other; i.e., 1. Manufacturer See note A Dennison DR AMINA TARIQ. BIOCHEMISTRY. Survival of a multicellular organism depends on their ability to adapt to the constantly changing environment.. Intercellular communication mechanisms are necessary for this adaptation.. Chapter 13, . Stryer. Short Course. Signal Transduction. Signal from exterior of cell must affect interior of cell. Through the membrane. Amplification of signal. Ability to turn off. A few pathways…. Organisms. can function normally only if:. All the cells of their different organs communicating effectively with their surroundings. . Once a cell picks up a hormonal or sensory signal, it must transmit this information from the surface to the interior parts of the cell—. . Signal Transduction Pathway. EXTRACELLULAR. FLUID. Plasma membrane. CYTOPLASM. Receptor. Signaling. molecule: ligand. Relay molecules in a signal transduction pathway. Activation. Essential idea: Hormones are not secreted at a uniform rate and exert their effect at low concentration. D.5 Hormones and metabolism. Understandings:. Endocrine glands secrete hormones directly into the bloodstream. Index. Introduction. Discovery. Linkage data from transduction. Specialized transduction. Lytic and Lysogenic Cycle. Introduction. Transduction is the process by which DNA. . is transferred from one bacterium to another by a virus.. Dr . Amena. . Rahim. Biochemistry. Biomedical Importance. Intercellular communication mechanisms are necessary requirements for this adaptation. . The nervous system and the endocrine system provide this intercellular, organism-wide communication. . Module . 10. WINS AND LEARNINGS. What were your success stories this week?. What results have you achieved so far?. Were you able to get more sleep this week and create a routine?. Did you work on managing your stress levels?. Organisms use feedback mechanisms to regulate growth and reproduction, and to maintain dynamic homeostasis.. Growth and dynamic homeostasis of a biological system are influenced by changes in the . system’s environment. . Z. Huang, Y. Chu, B. Cunha, and J. Hahn, Learning Objectives. Learn the general structure and properties of hormones.. Know the differences between Hormones, Neurotransmitters & enzymes. 3. . Understand . the general properties of signaling molecules (ligands), cell-surface receptors, & intracellular signal transduction components.. Cellular Signaling. Autocrine Signals . Diffuse from one part of a cell to another part of the same cell. Synaptic signaling. Neurotransmitter is the signaling molecule. Occurs in the animal nervous system.