PPT-Signal Transduction Pathways

Chapter 13 Stryer Short Course Signal Transduction Signal from exterior of cell must affect interior of cell Through the membrane Amplification of signal Ability to turn off A few pathways. . Enzyme-linked . receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. Organisms. can function normally only if:. All the cells of their different organs communicating effectively with their surroundings. . Once a cell picks up a hormonal or sensory signal, it must transmit this information from the surface to the interior parts of the cell—. Pratt & . Cornely. , Chapter 10. Terms for Signal Transduction. Ligand. Receptor. Transducer. Effector. Second messenger. Target proteins/DNA. Ligands. Hormones vs Local mediators. Polar (insulin) vs nonpolar (steroidal hormone). . Signal Transduction Pathway. EXTRACELLULAR. FLUID. Plasma membrane. CYTOPLASM. Receptor. Signaling. molecule: ligand. Relay molecules in a signal transduction pathway. Activation. Pratt & . Cornely. , Chapter 10. Terms for Signal Transduction. Ligand (first messenger). Receptor (transducer). Primary Effector. Second . messenger. Second effector, etc.. Target proteins/DNA. Ligands. Signal transduction . General features of signal transduction. Type of cell signalling. Type of Signal . transducer/Receptors. signal transduction. T. he . signal. . represents the information, . that is detected by specific . . Enzyme-linked . receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. . Enzyme-linked receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. Georgia Klein. Heroin. Comes from the seedpod of the opium poppy plant. Processed from morphine. It’s a depressant that inhibits the central nervous system and affects the brains ability to feel pain. Dr. Kevin Ahern. EGFR Signaling, Part 1. Epidermal Growth Factor Receptor (EGFR). EGFR Dimer. Autophosphorylated. Tyrosines in . Cytoplasmic Domain. Signaling Complex. Assembled on . Phosphotyrosines. LO 3.36: The student is able to describe a model that expresses the key elements of signal transduction pathways by which a signal is converted to a cellular response. SP 1.5: The student can re-express key elements of natural phenomena across multiple representations in the domain. More than 4 years experience in developing and analyzing mathematical models of complex bio-chemical reaction networks 10 Journal papers, 1 book chapter, 6 peer-reviewed conference papers, and 7 Cellular Signaling. Autocrine Signals . Diffuse from one part of a cell to another part of the same cell. Synaptic signaling. Neurotransmitter is the signaling molecule. Occurs in the animal nervous system. Outline. Review of Photosynthesis. Finish up Cam plants . Cell-Cell Communication. Local vs Long distance. Three Stages of Signaling. Reception. Transduction. Response. Photosynthesis - Overview. “Fixing” Carbon.