PPT-Hormones, Receptors, and Signal Transduction

Learning Objectives Learn the general structure and properties of hormones Know the differences between Hormones Neurotransmitters amp enzymes 3 Understand the general properties of signaling molecules ligands cellsurface receptors amp intracellular signal transduction components. DR AMINA TARIQ. BIOCHEMISTRY. Survival of a multicellular organism depends on their ability to adapt to the constantly changing environment.. Intercellular communication mechanisms are necessary for this adaptation.. Introduction. Lecture 3. Hormonal Actions Mediated by . Intracellular Receptors. The . cholesterol derivatives (steroid . hormones) . are lipid soluble and are thought to enter cells by diffusion through the lipid bilayer of the plasma . Organisms. can function normally only if:. All the cells of their different organs communicating effectively with their surroundings. . Once a cell picks up a hormonal or sensory signal, it must transmit this information from the surface to the interior parts of the cell—. . Signal Transduction Pathway. EXTRACELLULAR. FLUID. Plasma membrane. CYTOPLASM. Receptor. Signaling. molecule: ligand. Relay molecules in a signal transduction pathway. Activation. Signal transduction . General features of signal transduction. Type of cell signalling. Type of Signal . transducer/Receptors. signal transduction. T. he . signal. . represents the information, . that is detected by specific . Be ready to answer!. 3.D.3 Signal Transduction. Signal transduction pathways link signal reception with cellular response.. Many chemical messengers cannot cross the plasma membrane. . Signal transduction . . Enzyme-linked . receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. . Enzyme-linked receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. Receptor . Pharmacology . in . the . Peripheral . Nervous System (PNS. ):. a . Primer for . the. Cardiovascular. , Pulmonary, Renal. and . Musculoskeletal. (. MSK). . Modules. . E.M. . Silinsky. Ward 7-245 Tel: 503-8287. Dr . Amena. . Rahim. Biochemistry. Biomedical Importance. Intercellular communication mechanisms are necessary requirements for this adaptation. . The nervous system and the endocrine system provide this intercellular, organism-wide communication. . Dr. Kevin Ahern. EGFR Signaling, Part 1. Epidermal Growth Factor Receptor (EGFR). EGFR Dimer. Autophosphorylated. Tyrosines in . Cytoplasmic Domain. Signaling Complex. Assembled on . Phosphotyrosines. Vertebrates regulate the concentration of glucose in their blood at relatively constant levels.. They produce lost of dilute urine when they are over-hydrated, but they produce little very concentrated urine when they are dehydrated.. Cellular Signaling. Autocrine Signals . Diffuse from one part of a cell to another part of the same cell. Synaptic signaling. Neurotransmitter is the signaling molecule. Occurs in the animal nervous system. Alzayadneh. , PhD. Integrative Physiology and Pharmacology. 1. Introduction to Physiology (0501110) Spring 2013. Subject. Lecture No.. Lecturer. Pages in the 11. th. edition. textbook. Pages in the 12.