PPT-Hormones, Receptors, and Signal Transduction

Learning Objectives Learn the general structure and properties of hormones Know the differences between Hormones Neurotransmitters amp enzymes 3 Understand the general properties of signaling molecules ligands cellsurface receptors amp intracellular signal transduction components. Introduction. Lecture 3. Hormonal Actions Mediated by . Intracellular Receptors. The . cholesterol derivatives (steroid . hormones) . are lipid soluble and are thought to enter cells by diffusion through the lipid bilayer of the plasma . DR AMNA TAHR. ASSISTANT PROFESSOR. PHYSIOLOGY DEPARTMENT. KEMU. HORMONE. A  . hormone.   is a . chemical substance. produced in particular parts of organisms by specific cells, glands, and/or tissues and then transported to other parts of the body, with the intent of influencing a variety of physiological and behavioral activities, such as the . Organisms. can function normally only if:. All the cells of their different organs communicating effectively with their surroundings. . Once a cell picks up a hormonal or sensory signal, it must transmit this information from the surface to the interior parts of the cell—. . Signal Transduction Pathway. EXTRACELLULAR. FLUID. Plasma membrane. CYTOPLASM. Receptor. Signaling. molecule: ligand. Relay molecules in a signal transduction pathway. Activation. Chapter 45. You Must Know. How hormones bind to target receptors and trigger specific pathways. . The secretion, target, and regulation of at least two hormones. . An illustration of both positive and negative feedback in the regulation of homeostasis by hormones. . Signal transduction . General features of signal transduction. Type of cell signalling. Type of Signal . transducer/Receptors. signal transduction. T. he . signal. . represents the information, . that is detected by specific . Be ready to answer!. 3.D.3 Signal Transduction. Signal transduction pathways link signal reception with cellular response.. Many chemical messengers cannot cross the plasma membrane. . Signal transduction . . Enzyme-linked receptors. Nuclear receptors. Stochasticity. in . signalling. .. Enzyme-linked receptors. . signalling. through growth factors, hormones, cytokines. acting locally at very low concentrations (10. Receptor . Pharmacology . in . the . Peripheral . Nervous System (PNS. ):. a . Primer for . the. Cardiovascular. , Pulmonary, Renal. and . Musculoskeletal. (. MSK). . Modules. . E.M. . Silinsky. Ward 7-245 Tel: 503-8287. Dr. Kevin Ahern. EGFR Signaling, Part 1. Epidermal Growth Factor Receptor (EGFR). EGFR Dimer. Autophosphorylated. Tyrosines in . Cytoplasmic Domain. Signaling Complex. Assembled on . Phosphotyrosines. by cells of the immune system are specifically called "cytokines". The following arethe classical endocrine organs of humans:1. Thyroid glandThyroid gland located in the frontal portion of the neck, u Cellular Signaling. Autocrine Signals . Diffuse from one part of a cell to another part of the same cell. Synaptic signaling. Neurotransmitter is the signaling molecule. Occurs in the animal nervous system. Alzayadneh. , PhD. Integrative Physiology and Pharmacology. 1. Introduction to Physiology (0501110) Spring 2013. Subject. Lecture No.. Lecturer. Pages in the 11. th. edition. textbook. Pages in the 12. Introduction. Hormones are chemical messengers released from endocrine glands that travel through the blood system to influence the nervous system to regulate behaviors such as aggression, mating, and parenting of individuals..