PPT-Crystal digital PCR for detection and quantification of circulating EGFR mutations in

Author : jasmine | Published Date : 2022-06-11

Cécile Jovelet Postdocoral fellow Translational research lab Gustave Roussy Institute France Introduction 12042017 2 Lung cancer third most frequent cancer

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Crystal digital PCR for detection and quantification of circulating EGFR mutations in: Transcript

Cécile Jovelet Postdocoral fellow Translational research lab Gustave Roussy Institute France Introduction 12042017 2 Lung cancer third most frequent cancer NonSmall Cell Lung Cancer NSCLC 80 cases of lung cancer. Colin Reisterer and Nick Swenson. S. . Maheswaran. et al. . The New England Journal of Medicine. . 2007. http://www.all-cancer-treatments.com/types-of-lung-cancer.html. Clinical background: Non-small cell lung cancer (NSCLC). carcinoma. - . new. . biomarkers. Rafal. . Dziadziuszko. Medical. . University. of Gdańsk, Poland. Molecular. . aberrations. . in . lung. . adenocarcinoma. Driving. . molecular. . events. :. Arshed A. Quyyumi, MD . Professor of Medicine . Emory Clinical Cardiovascular Research Institute (ECCRI). Emory University School of Medicine. Atlanta, GA. Grant support: . National Institutes of Health, . TKI. s. . and . related. . treatment . strategies. Rafal . Dziadziuszko. Medical. . University. of Gdańsk, Poland. 16th European . Congress. „. Perspectives. in . Lung. Cancer. ” . Torino. The New EPOC Study. Randomi. ze. Surgery. Oxaliplatin. or . Irinotecan. w. ith FP . + . cetuximab. Surgery. 6 cycles . (3months). N. =268 . patients. Oxaliplatin. or . Irinotecan. w. ith FP . + . k. inase . i. nhibition. Danny Rayes . Lung Cancer and Epidermal Growth Factor Receptor. Lung cancer is a leading cause cancer-related death . Two types of lung cancer. Non small cell (NSCLC) 80-85%. The Coming Paradigm Shift. Faculty. Suresh S. Ramalingam, MD. Professor of Hematology/Oncology . Director, Lung . Cancer Program . Winship Cancer Institute. Emory University. Atlanta, . Georgia. Program Goals. TH TH H E R E R EAL EAL O ON N E S E S T EP R Pathogen and product description species are gram-negative, nonspore forming, spiral, or curved-shaped bacteria. Among the more than 26 species currentl EGF. Epidermal Growth Factor (EGF). Binds to . Epidermal Growth Factor . Receptor (EGFR). Results in . Cell Growth. Cell Proliferation. Cell Differentiation. Controls through the EGFR signaling pathway. Prediction. . and. . Data Sorting. Zhengtao. Li/06-24-2019. Introduction. https://www.ppdi.com/About/About-Drug-Discovery-and-Development. What . medchem. should focus?. IP. Target engagement. ADME property. Real-Time PCR is a specialized technique that allows a PCR reaction to be visualized “in real time” as the reaction progresses.. This enables researchers to quantify the amount of DNA in the sample at the start of the reaction!. Ana Rima. Lung Cancer: Incidence and Mortality. New cases in 2013: 228,190. 40% with stage IV disease at presentation (~ 90,000). ~ 160,000 deaths in 2012, comparable to prostate, pancreas, breast, and colon cancer combined. Tang A, Tong Z, Wang H, Dai Y, Li K, Liu J, et al. Detection of Novel Coronavirus by RT-PCR in Stool Specimen from Asymptomatic Child, China. Emerg Infect Dis. 2020;26(6):1337-1339. https://doi.org/10.3201/eid2606.200301. Gregory J. Riely. November 2021. What about those other EGFR mutations?. EGFR. ALK. ROS1. BRAF. RET. MET Exon14. KRAS G12C. EGFR exon 20. ERBB2/HER2. NTRK. Key Subtypes. EGFR exon 20 insertions . ~1% of people with NSCLC.

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