PPT-Crystal digital PCR for detection and quantification of circulating EGFR mutations in

Author : jasmine | Published Date : 2022-06-11

Cécile Jovelet Postdocoral fellow Translational research lab Gustave Roussy Institute France Introduction 12042017 2 Lung cancer third most frequent cancer

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Crystal digital PCR for detection and quantification of circulating EGFR mutations in: Transcript

Cécile Jovelet Postdocoral fellow Translational research lab Gustave Roussy Institute France Introduction 12042017 2 Lung cancer third most frequent cancer NonSmall Cell Lung Cancer NSCLC 80 cases of lung cancer. DNA pol error rate . ~. 10. -9. per base . copied. How many errors in a . “typical” . somatic cell?. Most errors don’t have detectable effects. But some errors do: . . oncogenes. N. . – dominant. Circulating Tumor Cells (CTC). Metastasis. : the spread of cancer from its primary site to other places in the body.. Metastatic disease is the most common cause of cancer-related death in patients with solid tumors.. Colin Reisterer and Nick Swenson. S. . Maheswaran. et al. . The New England Journal of Medicine. . 2007. http://www.all-cancer-treatments.com/types-of-lung-cancer.html. Clinical background: Non-small cell lung cancer (NSCLC). carcinoma. - . new. . biomarkers. Rafal. . Dziadziuszko. Medical. . University. of Gdańsk, Poland. Molecular. . aberrations. . in . lung. . adenocarcinoma. Driving. . molecular. . events. :. Synthesis of Control Circuits. by A. . . Steininger. and J. . Lechner. Vienna University of Technology. Lecture "Advanced Digital Design" . © A. Steininger & J. Lechner / TU Vienna. 2. Outline. Cell Free Circulating . DNA in Detecting EGFR Mutations Present in Tumor . Tissue. S. Das. 1. , L. Bazhenova. 2. , V. Singh. 3. , L. Arnold. 3. , V. Alexiadis. 3. , T. Watanaskul. 3. ; . 1. Internal Medicine, Division of Hematology-Oncology, University of California San Diego, La Jolla, CA/United States of America, . k. inase . i. nhibition. Danny Rayes . Epidermal Growth Factor Receptor. EGF + EGFR .  growth and proliferation. Mutant EGFR (no ligand) .  growth and proliferation. Inhibiting activating mutations. k. inase . i. nhibition. Danny Rayes . Lung Cancer and Epidermal Growth Factor Receptor. Lung cancer is a leading cause cancer-related death . Two types of lung cancer. Non small cell (NSCLC) 80-85%. The Coming Paradigm Shift. Faculty. Suresh S. Ramalingam, MD. Professor of Hematology/Oncology . Director, Lung . Cancer Program . Winship Cancer Institute. Emory University. Atlanta, . Georgia. Program Goals. Consequences of the Lack of Patients of color & Structural barriers to Quality. Christopher S. Lathan, M.D., M.S., M.P.H. Assistant Professor of Medicine. Faculty Director of Cancer Care Equity, Dana-Farber Cancer Institute. Growth Factor Receptor (EGFR) mutants and its Clinical Implications. . Jeonghee Cho. Samsung. . Genome Institute. Samsung Medical Center . Outline. Mechanistic insight of . cetuximab. -based EGFR targeted therapy . Prediction. . and. . Data Sorting. Zhengtao. Li/06-24-2019. Introduction. https://www.ppdi.com/About/About-Drug-Discovery-and-Development. What . medchem. should focus?. IP. Target engagement. ADME property. The market for circulating tumour cells is primarily driven by the rising understanding of
their diagnostic and clinical utility, which has prompted an increase in circulating tumour cell research in
an effort to develop efficient diagnostic tools. in . solid. . tumors. Roberto Bianco. Università degli Studi di Napoli Federico II. robianco@unina.it. c. MET. Receptor Structure. MET is a receptor tyrosine . kinase. MET gene located on chromosome 7 (7q21–q31).

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