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IgG4 hNF155Myc hNF155Myc hNF155Myc Myc Myc Myc Myc Merge Merge Merge Merge B OD. Class switch recombination. Membrane vs secreted. mutation, . selection. Low . affinity. High. affinity. Affinity maturation. IgE. Constant region. (. function. ). Variable region. (. antigen-binding. published online May 23, 2011J. Biol. Chem.    10.1074/jbc.M111.255026Access the most updated version of this article at doi:  Alerts:   When a correction for this article is posted•  Therapeutic monoclonal antibodies (mAbs) are biologics that have been used for decades to treat various conditions, including rheumatoid arthritis, asthma, as well as various cancer s and infect ACTIVE vs ADVANTAGES AND DISADVANTAGES OF EACH APPROACH Arturo Casadevall Albert Einstein College of Medicine Bronx, New York DEFINITIONS • ACTIVE IMMUNIZATION = VACCINES • PASSIVE IMMUNIZATION = Downloaded from http://rupress.org/jem/article-pdf/137/2/265/1085203/265.pdf by guest on 28 October 2022 Downloaded from http://rupress.org/jem/article-pdf/137/2/265/1085203/265.pdf by guest on 28 Oct Imbokodo. HIV-1 vaccine efficacy trial. Late Breaker Track A. Avi Kenny, Department of Biostatistics, University of Washington, Seattle, USA. The . Imbokodo. trial was supported by a public-private partnership led by Janssen Vaccines & Prevention B.V., the National Institute of Allergy and Infectious Diseases, the Bill & Melinda Gates Foundation, and the HIV Vaccine Trials Network (HVTN). Additional partners providing support included the U.S. Army Medical Research and Development Command (USAMRDC) and the .