PPT-Non-Destructive and Rapid Skeletal Visualization in DART studies

Michael Johnson 1 Thomas Villani 1 Nick Crider 1 Colleen Wojenski 2 1 Visikol Inc North Brunswick NJ 08902 2 Product Safety Labs Dayton NJ 08810 Abstract Developmental and reproductive toxicology DART studies are required for new chemical entities going to market to ensure that there are not adverse developmental consequences associated with the chemical These studies involve dosing a pregnant female animal eg mouse rat rabbit with the compound and evaluating the effect of the chemical on the offspring This evaluation involves the parallel processes of histopathology and gross morphological evaluation wherein the most timeconsuming component of DART studies is the performance of gross skeletal evaluation Since the introduction of Thalidomide into the marketplace close attention has been paid to the impact of chemicals on skeletal development and DART studies require the visualization of gross skeletal morphology for abnormalities The current methodology for conducting skeletal evaluation involves digesting soft tissue using a strong base potassium hydroxide and staining the bone with alizarin and cartilage in some cases with . Jazz . Slappey. Ms.Carter. 5. th. Grade. December 1, 2015. What are Constructive Forces?. Constructive Forces are processes that help build or construct the Earth.. Constructive forces can deposit soil or silt in a river.. Constructive Forces. A constructive force is on that build up the Earth’s surface.. B. Examples: . Mountain building . Deposition of sediment. Volcanic Eruption. August 2006 brought two new things to the . Constructive. vs. . Destructive. Processes. Constructive vs. Destructive. Constructive forces affect the earth's surface by building it up while forming new crust and landforms like mountains, islands, deltas, and sand dunes.. Answer questions provided by the teacher. . If you are correct, choose a dart. . Keep score. . Choose Dart Board. 1. 2. 3. 4. 5. 6. 7. 8. New Dart Board . 3. 5. 7. 1. New Dart Board . 3. 5. 7. 1. New Dart Board . What are Destructive Forces?. A destructive force is a process that lowers or tears down the surface features of the Earth. . Examples of Destructive Forces:. Destructive forces can occur in many ways. The following are common examples of destructive forces:. Presented By. Cheryl D. Orr, SPHR, IPMA-SCP. Vice President of Human Capital. June 20, 2017. MAX Program. – Partnership with DART, LA METRO, MARTA, RTD. Leadership DART . – Partnership with Southern Methodist University. A Crisis/Disaster Behavioral Health Decision-making Tool. Mark R. Marquez, LCSW, MSW, . EdD. Fayetteville State University. eSocialWorker. LLC. During . crises, such as disaster, the luxury of an overabundance of time, resources, or personnel generally does not exist. Additionally, communication within and between responders and response systems can be confusing.. The Office of Board Support. Laneshia Hawkins. Board Support Specialist. June 19, 2017. Agenda. History of the DART Board . Function of the Board . Board Member Appointments. Board Meetings. Functions of the Office of Board Support. Sabrina Barner, Abbe Carlin, Amber Weigle. Neuromuscular Junctions. Communication link between nervous system and skeletal muscle fiber. Specialized intercellular connection. Each skeletal muscle fiber is controlled by a nerve cell. The Skeletal System . Skeletal System – bones of the body, shields important organs, gives your body shape. Skull protects the brain / Ribs Protect your heart and lungs / Back bone protects your spinal cord. 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PROGRAMMING LANGUAGE DART. Open-source. Structured. Flexible. Developed by Google. Primarly used for Web applications, but with new version, Dart is used even in Mobile applications and in Desktop applications. 1. Overview. Object Oriented Language. Developed By Google. Primarily used for building websites, servers, and mobile apps. Provides librariries, an editor, a virtual machine (VM) and a compiler to javaScript.