PPT-MLAB 2401: Clinical Chemistry

Keri Brophy Martinez Methods of Glucose Measurement and Diabetic Management Laboratory testing Considerations Reference values depend on Type of specimen venouscapillary Serum plasma whole blood. Courses for Entry into the Doctor of Pharmacy [Pharm.D.] Program 8/2014 Chemistry General Chemistry I with lab - 4 - 5 hours General Chemistry II with lab - 4 - 5 hours a Organic Chemistry I with lab Keri Brophy-Martinez. Automation. History of Automation. 1957. Technicon. develops the first automated analyzer. Continuous flow. Issues: carryover and costly. 1970. Dr Anderson(NASA) develops a centrifugal analyzer. Keri Brophy-Martinez. Designs in Instrumentation. Electrochemistry. Electrochemistry. Basic principle. Electrodes are used to selectively measure particular ions. Instruments utilizing electrodes measure the potential difference (charge) that builds up at an interface when two different . MLAB 2431 Keri . Brophy. -Martinez. Overview:. Amino Acids & Proteins. Amino Acids. Building blocks of proteins. Chemical properties determine biological activity. Origin. Majority made in the human. Generated from amino acid pool. Keri Brophy-Martinez. Measurement of . Enzymes & Their Clinical Significance. Measurement of Enzyme Activity. Often measured by catalytic activity then related to . concentration. Enzyme concentration is best measured by its activity or its rate of activity by observing:. Chemistry. Keri Brophy-Martinez. Point of Care Testing . 1. Point of Care Testing. Analytical patient - testing activities provided within the institution, but performed outside the physical facilities of the clinical laboratories. Keri Brophy-. M. artinez. Anemia. Part Three. RBC Shape Variations. Alterations in the shape of the RBC is called . poikilocytosis.. 2. Target Cells (Codocytes) . Occur due to an increased red blood cell surface area. . Keri . Brophy. -Martinez. Anemia. Part Two. The “Normal” RBC. Biconcave disc. Area of central pallor. Approx. size 7 µm. RBC Size Variations. Alterations in the size of the RBC is called . anisocytosis. Keri . Brophy. -Martinez. ABG Interpretation. Evaluating Acid-Base Disorders. ARMADA . acid-base balance made easy in 4 steps . 1. . A. . cidosis. or Alkalosis?. 2. . R. . espiratory. disorder?. • What is “Inorganic Chemistry”?. . - descriptor or professional subfield. . - same as “General Chemistry”?. • Highlights from the inorganic timeline. . - Lavoisier: origin of modern chemistry. Our Team. 14 staff members:. Medical Director, James . Corsetti. , MD, PhD. 1 Secretary.. 1 Administrator.. 1 Asst. Supervisor . . 11 Med. Technologists. . Red Creek Laboratory. Hematology &. Coagulation. Bridging the gap between the clinical laboratory and medical management by relating pathophysiology to analytical results in health and disease, this classic resource provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Its up-to-date, encyclopedic coverage of the field defines analytical criteria for the medical usefulness of laboratory procedures, introduces new approaches for establishing reference ranges, describes variables that affect tests and results, examines modern analytical tools and their impact on lab management and costs, and demonstrates the applications of statistical methods.All three editors are well known in the clinical chemistry world, and they bring a wealth of expertise to this reference.Encompasses the tremendous strides made in clinical laboratory medicine in recent years - keeping readers completely up to date.Nearly 800 tables and figures illustrate key issues in clinical chemistry.A comprehensive chapter containing tables of reference values provides one location for comparing and evaluating test results.A section has been added that contains 8 new chapters that focus on emerging issues and techniques in molecular diagnostics and genetics.Co-editor David Bruns, the editor of Clinical Chemistry, provides an authoritative look into laboratory medicine in general and specifically in the field of molecular technology. The Fifth Edition of this classic text is revised and updated to incorporate the latest technologies, techniques, and opportunities in clinical chemistry. No other text is more careful to strike a balance between analytical principles and techniques and the correlation of laboratory results. This edition features additional case studies and questions, expanded coverage of endocrinology, and updated information on toxicology, geriatrics, and other topics.An Instructor\'s Resource Guide on CD-ROM includes chapter review questions and answers, teaching tips, an image bank, curriculum guidelines, and pedagogy by chapter.