PPT-Protein-protein

Interactions June 6 2017 Why PPI Proteinprotein interactions determine outcome of most cellular processes Proteins which are close homologues often interact in the same way Proteinprotein interactions place evolutionary constraints on protein sequence and structural divergence. Muhammad Shoaib Amjad. 11-Arid-3758. PhD Botany. WHY PROTEIN FOLDING?. Most proteins must fold into defined three-dimensional structures to gain functional activity. . SUMI SINGH. (sxs5729). Levels of Protein Structure. 2. Thanks to: Frank . Lloyd . Wright for graphics. WOOD, BRICK etc. . . material/building blocks . AMINO ACIDS. *****************************************************************. TFIIF. TFIIA. RNA Pol II. TFIID. TFIIB. core promoter. exon 1. Cactus. Dorsal. Dorsal. Tube. Pella. Pella. Tube. Spatzle. Toll. So. Eya. Su(H. ). CtBP. Gro. Delta. Kuz. Detecting Protein-Protein Interactions. The production of a mature protein is a multistep process in eukaryotic cells. . The final folded configuration, or shape, of a protein is determined by its amino acid sequence.. Most proteins require the assistance of molecular chaperones, like Hsp70 & Hsp60, to reach their final folded form.. Interactions. June 18, 2015. Why PPI?. Protein-protein interactions determine outcome of most cellular processes. Proteins which are close homologues often interact in the same way. Protein-protein interactions place evolutionary constraints on protein sequence and structural divergence. DNA .  RNA  Protein. 2 Major Steps. Transcription. – DNA is transcribed (copied!) into single stranded mRNA . (DNA code transcribed into RNA code). Translation. – mRNA is translated into protein (amino acids). Food fact. Proteins contain 4 calories per gram.. Protein . is a very important nutrient. It makes up most of our body cells, tissues and fluids. .. Protein . Deficiency. -Leads to Kwashiorkor in children Happens mostly in impoverished countries where there is a lack of protein rich foods. . 36. Which . of the following statements best describes the structure of DNA. ?. A. . Two strands of proteins are held together by sugar . molecules. , . nitrogen bases, and . phosphate groups.. B. . EGGS. &. OTHER PROTEIN SOURCES. Foods I: Fundamentals. PROTEIN. SOURCES of protein:. Eggs, fish, red meat, poultry, nuts, beans, dairy. Our body needs 2-3 servings of protein daily so that we are able to:. A nutrient found in all living things. It contains nitrogen and is responsible for the formation, maintenance, and repair of the body’s tissues/ It can also be used for energy. CHNO. Amino acids . ů hmotnostní spektrometrií. C7250. Část . V. Zbyněk Zdráhal. Výzkumná. . skupina. . Proteomika. , CEITEC-MU. Centrální. . laboratoř-Proteomika. , CEITEC-MU. Funkční. . genomika. a . URGXFWQDPH RWH D[LPXPELQGLQJFDSDFLW\ PJP/UHVLQ %LSR5HVLQ3 URWHLQ$ ONDOLQH5HVLVWDQFH ONDOLQH HVLV Proteins are major components of all cellular systems. Proteins consist of one or more linear polymers called polypeptides. Proteins are linear and never branched. Different AA’s are linked together via . Prediction . Wang Yang. 2014.1.3. Outline. Molecular. . Co-evolution . phenomenon. A. pplications . of Co-evolution . in . protein structure prediction and PPI prediction.. Co-evolution measurement: .