PPT-Platelet Function disorders in Neonate

Mohammad FaranoushMD Professor of pediatric Hematology Oncology Iran University of Medical Sciences Rasool Akram Medical Complex Disclosures No conflict of interest Introduction Platelets play a crucial role in hemostasis. Platelets aggregation. Studying Platelets Disorders. . Numbers. . CBC. PLT count. PLT morphology. Function. . Bleeding . Time (BT). Platelet Aggregation. Whole blood aggregation . Platelet-rich plasma aggregation. Joanna Rupa-Matysek. Hemostatic. System - . general. . information. Normal . hemostatic. system . vessel wall. circulating blood platelets. blood coagulation and . fibrynolysis. Bleeding. . Diathesis. University. Faculty of Applied Medical Sciences. Department Of Medical Lab. Technology. 3. rd. Year – Level 5 – . AY 1434-1435 . 1. Hematology – 2, MLT 307. Bleeding disorders. . caused by . Thrombocytes. Platelets (Thrombocytes). 2- 4 micromillimeters in diameter. 250,000 – 400,000 per microliter . (too few thrombocytopenia – too many thrombocytosis). Lifespan on average 6 – 10 days. Autoimmune (ITP). Childhood. Adult. Drug-induced. Heparin. Quinine, others. Immune complex (infection, etc). Alloimmune. Post-transfusion purpura. Neonatal purpura. ITP. Childhood ITP (most < 10 . purpura. (ITP). Immune thrombocytopenia . purpura. (ITP). 1- Chronic ITP: . This is relatively common disorder ,with highest incidence in . women. . 15-50 y. ,it is commonest cause of thrombocytopenia without anemia or neutropenia ,it is usually . thrombocytopenia. ) constitutes an important cause of generalized bleeding.. A count less than 100,000 platelets/. μL. is generally considered to constitute thrombocytopenia. . Platelet counts in the range of 20,000 to 50,000 platelets/. Dr Arvind . gupta. Assistant . professor pathology. Primary haemostasis involves the binding of platelets to exposed collagen in the sub endothelium of damaged vessels.. Secondary haemostasis is the process of activation of coagulation factors leading to the production of thrombin.. Us / Mohammed Omballi . MSc. Hematology & immunohematology . The mechanism by which the blood kept in side . the blood . vessels in a fluid . state, . without clotting and stop bleeding . hemostasis. Focus on neonatal emergencies. 2. . and . 3 . October. 2019. For ST4-ST8 . R. egistrars, AANPS, Senior . F. ellows or Consultants . To book . your. place: . . Ishfaq. . Bukhari. Dec. 2012. In healthy vasculature, circulating platelets are maintained in an inactive state by nitric oxide (NO) and . prostacyclinre. (PGI2)leased by endothelial cells lining the blood vessels.. : . Professor . David Lane. . Abnormalities of . haemostasis. - Professor Mike . Laffan. Department of . Haematology. Hammersmith Hospital . C. ampus. (d.lane@imperial.ac.uk; m.laffan@imperial.ac.uk). : . Haematology 5. . and . 6. 0900 . Lecture: . Haemostasis. : . Professor . David Lane. Film. . 10.00 . Lecture: Abnormalities of . Haemostasis. : . Dr Carolyn Millar. Department of Haematology. Hammersmith Hospital Campus. Workstream. Dr. Brian Tehan. MD for Quality & Transformation. BCUHB. brian.tehan@wales.nhs.uk. Stephanie Ditcham. Blood Health Advisor and Scientific Lead, . North . Wales. ,. Welsh Blood Service.