PPT-Dopamine, Motivation and Schizophrenia: Research with Rodent Models

Department of Psychology Program in Neuroscience John D Salamone PhD CNRTRICS 2010 RO1MH78023 RO1NS047261 DA009158 BACKGROUND DA and Schizophrenia Strong and Weak Forms of the DA Hypothesis. Interest in dopamine was intensified by the realisation that dopamine had an important role in the pathogenesis or drug treatment of certain brain History diseases eg Parkinsons disease schizophrenia This lead to much research on the sites of action Salient Features:. Centralised. Reporting and Monitoring System. Facility to test all controllers in one go or in an individual mode.. R-SCAT DIGITAL RODENT REPELLENT . Salient Features:. User friendly setup to configure number of machines , number of ping tries, ping return time. Facility to configure R-Scat Controller parameters for all controllers in one go ( . Dr. Stephen M. Stahl. 1. LAT500-15 revised November 2015. Learning Objectives. To learn about neuroregulation of schizophrenia . symptomatology. . To understand current hypotheses of schizophrenia and how they influence treatment. The function of neurotransmitters. What is this?. What does it do?. Where are the neurotransmitters?. Can you name any neurotransmitters?. Lets remind ourselves how neurotransmitters work. Lets remind ourselves how neurotransmitters work. Ms. . Carmelitano. Acetylcholine. First Neurotransmitter to be identified and most common in the human body. Function: . Helps control muscle contraction. Plays a role in the development of memory of the hippocampus. Chris Perkins. Alzheimers NZ Conference. 04/11/16. Increased life expectancy. Challenge of diagnosing dementia. Risk reduction. Management . Life expectancy. Schizophrenia. Life expectancy lags by 12 years in women and 15 years in men with schizophrenia (Casey et al , 2011) Some others say 20 years difference.. Philip . Cofoid. Prevalence of 0.3% to 0.5% worldwide. Before antipsychotic drugs, the outcome of schizophrenia usually resulted in:. Catatonic states. Institutionalization. Complete debilitation. Antipsychotics have not only made schizophrenia manageable, they immensely improve the quality of life of the patients. Schizophrenia. “. Schizein. ” (Greek) for “to split”. “. phren. ” (Greek) “mind”. *Often mistaken for “Split personalities”. *Means SPLIT from REALITY.. Symptoms. Positive Symptoms ( = ADD). 2012. 1. Psychosis. Psychosis may be substance-induced or caused by brain injury, but most psychoses appear in the form of schizophrenia. Psychosis is a state defined by a loss of contact with reality. Outline. Introduction. . History . Epidemiology. Etiology . Psychosis. Severe form of mental disorder. Greater severity of illness. Lack of insight. Inability to distinguish between subjective experience and reality (hallucinations & delusions). Dopamine and It’s Uses. Neurotransmitter. Helps transmit signals in brain and other vital areas. Found in humans and animals, including vertebrates and invertebrates. Mainly inhibitory. Involved in voluntary movement, learning, arousal, and feelings of pleasure. Tufts Ex College. March 11, 2014. http://. skeptikai.com. /. A pattern of broken thoughts: . Schizophrenia, A Beautiful Mind, and Fight Club. Schizophrenia is a . syndrome. : . A. . collection of signs and symptoms of unknown . odihesh. Consultant child & adolescent psychiatrist. Psychotic Disorders . are mental illnesses characterized by gross impairment in reality testing and personal . functioning. Its symptoms . include dysfunctions . “... a psychiatric disorder, falling within the scope of psychotic illnesses, meaning that the patient at some point develops symptoms that lead them to misinterpret reality.”. . (. Picchioni. & Murray, .