PPT-Dopamine, Motivation and Schizophrenia: Research with Rodent Models

Department of Psychology Program in Neuroscience John D Salamone PhD CNRTRICS 2010 RO1MH78023 RO1NS047261 DA009158 BACKGROUND DA and Schizophrenia Strong and Weak Forms of the DA Hypothesis. Department. of Psychology. Program. in Neuroscience. John D. . Salamone PhD. CNRTRICS 2010. RO1MH78023. RO1NS047261. DA009158. BACKGROUND. DA and Schizophrenia: Strong and Weak Forms of the DA Hypothesis. A command and control center for our simultaneous multiple constraint satisfying machine. . Outline. Staying alive and maintaining Homeostasis. P. erception. Motivation and Effort. Emotions & Habits. UNIT 4: PSYA4. lcb@beauchamp.org.uk. . Topic Content. In relation to their chosen disorder:. Schizophrenia. Depression. Phobic disorders. OCD.  . Candidates should be familiar with the following:. Clinical characteristics of the chosen disorder.. The function of neurotransmitters. What is this?. What does it do?. Where are the neurotransmitters?. Can you name any neurotransmitters?. Lets remind ourselves how neurotransmitters work. Lets remind ourselves how neurotransmitters work. The function of neurotransmitters. What is this?. What does it do?. Where are the neurotransmitters?. Can you name any neurotransmitters?. Neurotransmitter molecules are released from the end of the presynaptic cell (the axon) into the space between the two nerve cells (the synapse). Having travelled across the synaptic gap or cleft, molecules may then be ‘taken up’ by specially shaped receptor sites on the postsynaptic nerve cell (the dendrite) and so the chemical message is passed on. The relationship between the neurotransmitter molecule and the receptor site is like a lock and key, molecules will only fit certain receptor sites.. NETWORK INTERACTIONS IN SZ – THERAPEUTIC IMPLICATIONS. Awarded the Nobel Peace prize for their work on neural transmission.. Arvid. is best known for his work into the relationship between dopamine and Parkinson’s disease.. Philip . Cofoid. Prevalence of 0.3% to 0.5% worldwide. Before antipsychotic drugs, the outcome of schizophrenia usually resulted in:. Catatonic states. Institutionalization. Complete debilitation. Antipsychotics have not only made schizophrenia manageable, they immensely improve the quality of life of the patients. Schizophrenia. “. Schizein. ” (Greek) for “to split”. “. phren. ” (Greek) “mind”. *Often mistaken for “Split personalities”. *Means SPLIT from REALITY.. Symptoms. Positive Symptoms ( = ADD). Schizophrenia. 1. Introduction to neuroanatomy. 2. Organisation of the nervous system. To understand psychiatric disorders, it is important to understand the normal structure and function of the nervous system. symptoms. Schizophrenia is the most common psychotic illness and characterised by two sets of symptoms; symptoms present during the acute phase; and those present when the illness is well established (chronic).. Anthony A. Grace, Ph.D.. Departments of Neuroscience, . Psychiatry and Psychology. University of Pittsburgh. . - Schizophrenia is a genetically linked disorder with multiple risk factors contributing to its expression. Introduction. Disorders on the schizophrenia spectrum. Involve psychosis, . impaired cognitive processes, . unusual or disorganized motor behavior, . social withdrawal. Symptoms of Schizophrenia Spectrum Disorders. Objectives:. . List the classification of antipsychotic drugs used in schizophrenia.. Describe briefly the mechanism of antipsychotic action of these drugs. . Describe the pharmacological actions of antipsychotic drugs. . “... a psychiatric disorder, falling within the scope of psychotic illnesses, meaning that the patient at some point develops symptoms that lead them to misinterpret reality.”. . (. Picchioni. & Murray, .