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Hedgehog and Notch Hedgehog and Notch

Hedgehog and Notch - PowerPoint Presentation

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Uploaded On 2017-05-23

Hedgehog and Notch - PPT Presentation

signaling Drosophila Hedgehog Hh pointy denticles Tabins lab identfied 3 Vertebrate genes with homology to Hh Sonic Hedgehog Shh Widespread useage in dev Particularly in NT and ID: 551162

figure hedgehog arrow notch hedgehog figure notch arrow sonic limb protein chick expressed pathway syndromes malformation congenital gut gli3

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Presentation Transcript

Slide1

Hedgehog and Notch

signaling

Slide2

Drosophila Hedgehog (Hh) pointy denticles

Tabin’s lab identfied 3 Vertebrate genes with homology to Hh:Sonic Hedgehog (Shh) Widespread useage in dev. Particularly in NT and limb developmentDesert Hedgehog (Dhh) Sertoli cells mice -/- defective spermatogenesisIndian Hedgehog (Ihh) gut and cartilage

Hedgehogs: role in vertebrate development and

some Human congenital malformation syndromesSlide3

Figure 3.25 Hedgehog signal transduction pathwaySlide4

Figure 3.26 Sonic hedgehog is shown by in situ hybridization to be expressed in the nervous system (red arrow), gut (blue arrow), and limb bud (black arrow) of a 3-day chick embryoSlide5

Model of major postulated interactions in the patterning of the somite

Signaling between NT, Nc and somite Slide6

Inherited congenital malformation syndromes

in HumansGrieg cephalopolysyndactyly

: high forehead and

increased # of digits(results from a non functional truncation

of the Gli3 protein)

Pallister Hall syndrome

lethal shortly after birth- Gli3 DBD intact

but no TAD (Dom Neg)

Ectopic activation of Hh pathway in somatic tissues

:

Eg heritable mut in Patched gene (no inhibition of Smo):

Developmental abnormalities, fused fingers, rib and facial defects

Basal cell carcinomasSlide7

Skeletal

pattern of the chick wingSlide8

Sonic

hedgehog protein is expressed in the ZPA Slide9
Slide10
Slide11
Slide12

Head of a cyclopic lamb born of a ewe who had eaten Veratrum

californicum

early in pregnancySlide13

Figure 3.33 Mechanism of Notch activity (Part 1)Slide14

Figure 3.33 Mechanism of Notch activity (Part 2)Slide15