Pharmacology Instructor Health Sciences Faculty University of Mendoza Argentina Psychiatry Resident Mental Health Teaching Hospital Dr Carlos Pereyra Mendoza Argentina Flavio ID: 784948
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Slide1
Dopamine pathways & antipsychotics
Pharmacology Instructor
Health Sciences FacultyUniversity of MendozaArgentinaPsychiatry ResidentMental Health Teaching Hospital “Dr. Carlos Pereyra “ MendozaArgentina
Flavio
Guzmán
, MD
Slide2Learning objectiveUnderstand basic concepts of dopaminergic pathways and their relevance to antipsychotic effects.
Slide3Dopaminergic pathways: outline
The physiological processes under
dopaminergic control include reward, emotion, cognition, memory, and motor activity. Dysregulation of the dopaminergic system is critical in a number of disease states, including Parkinson disease, Tourette's syndrome, bipolar depression, schizophrenia, attention-deficit hyperactivity disorder, and addiction/substance abuse. Mesolimbic pathway (positive symptoms) Mesocortical pathway (negative symptoms) Nigrostriatal pathway (EPS and TD)Tuberoinfundibular pathway (hyperprolactinemia)
Slide4Mesolimbic pathway & positive symptoms of schizophrenia
Slide5Mesocortical pathway: negative & cognitive symptoms
Slide6Nigrostriatal
pathway & EPS
Slide7Tuberoinfundibular pathway & prolactin release
Slide8Summary
Hyperactivation from the VTA to
limbic areas might be related to positive symptoms of schizophrenia.Hypofunction of the mesocortical pathway might in part explain cognitive and negative symptoms of schizophrenia.D2
blockade
of
the
nigrostriatal
pathway
can cause EPS.
D2
blockade
of
the
tuberoinfundibular
pathway
increases
prolactin
blood
levels
.