PPT-CARCINOMA (BRCA) LEC 2 Dr.Eaman

suud khalifa Learning objectives Discuss epidemiologyampRisk factors for Breast carcinoma Carcinoma in situamptheir types Paget disease of the nipple Pathological types of breast . Annual Ob-Gyn Update. Ovarian Cancer:. Finally. . We Can Start To Talk About Prevention!. Walter Kinney M.D.. Division of Gynecologic Oncology. The Permanente Medical Group. Clinical Professor of Ob/Gyn, U.C. Davis. 21 yo female px to GP with 3/52 of severe abdominal pain colicky in nature with no relieving sx . Associated with nausea and reduced appetite. 2 . p. resentation to ED with nil Ix. PMHX:. Asthma. Social HX:. Talking point:. Genetics of ovarian cancer. 49F. Underwent risk-reduction surgery. Total hysterectomy and bilateral . salpingo. -oophorectomy. Significant family history . Sister passed away in her 40s due to breast cancer. Opinion. 55 year-old woman with . recurrent . ovarian cancer. Underwent an optimal . cytoreductive. surgery and placement of an intraperitoneal catheter. Disease progressed through multiple lines of chemotherapy. Inhibitors:. Purpose and Practicalities . Presenter. Charlie Gourley, . MBChB, PhD, FRCP. Professor of Medical Oncology. University of Edinburgh. Edinburgh, Scotland, United Kingdom. Topics for Discussion. proceedings from the live CME event and may include . the use of trade names and other raw, unedited content. . Module 1: PARP Inhibition as a Therapeutic Strategy — Ovarian Cancer (OC) at the Vanguard . TheXevaUser'sGuide1Introduction TheXevapackageprovidesecientandpowerfulfunctionsforpatient-drivedxenograft(PDX)basedpharmacogenomicdataanalysis[1].2InstallationandSettings Xevarequiresthatseveral 2ABCAUC.............................................5batchInfo..........................................5brca.............................................6createXevaSet................................ khalifa. . Etiology of cancer . Many factors may play a role in etiology of cancer:.  . I. Geographical & environmental factors:. These factors . form about 65% of all cancer etiology, while genetic factor form about 26%- 42% of cancer etiology. II.Rate of growth. Most . benign tumors grow slowly . & most of cancers grow faster . & eventually spread locally & to distant sites (metastasis) & causing death.. In some exception, some benign tumors grow more rapidly than some cancers e.g. leiomyoma (uterine fibroid), which is benign smooth muscle tumor influence by estrogen & so increase in size during pregnancy.. . 2. TUMORS OF THE BREAST. Fibroadenoma. . Is the most common benign neoplasm of the female breast.. An increase in estrogen activity is thought to contribute to its development, and indeed similar lesions may appear with fibrocystic changes (. CESC. CESC. CHOL. CHOL. COAD. COAD. DLCB. DLCB. ESCA. ESCA. GBM. GBM. HNSC. HNSC. A. B. C. D. E. F. G. H. I. J. K. L. Q. R. M. N. O. P. S. T. KIRP. KIRP. LAML. LAML. LGG. LGG. LIHC. LIHC. LUAD. LUAD. . S. uud. LEC.1. Learning objectives:. Discuss benign breast diseases like fibrocystic changes ,types of mastitis ,fat necrosis. Sclerosing. . adenosis. , Duct . ectasia. in addition to benign tumors like . Genetics of ovarian cancer. 49F. Underwent risk-reduction surgery. Total hysterectomy and bilateral . salpingo. -oophorectomy. Significant family history . Sister passed away in her 40s due to breast cancer.