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Histoire naturelle de l’infection à papillomavirus humai
Histoire naturelle de l’infection à papillomavirus humai

Histoire naturelle de l’infection à papillomavirus humai - PowerPoint Presentation

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Histoire naturelle de l’infection à papillomavirus humai - Description

du tissu sain au cancer JeanDamien Combes 1 pour Silvia Franceschi 1 Christine Clavel 2 et Jean Lacau Saint Guily 3 1 International Agency for Research on Cancer Lyon France ID: 541910 Download Presentation

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lesions hpv tonsils infection hpv lesions infection tonsils tonsil detection reims split jean induced cancerous tenon study iarc cytology

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Presentation on theme: "Histoire naturelle de l’infection à papillomavirus humai"— Presentation transcript

Slide1

Histoire naturelle de l’infection à papillomavirus humain dans les amygdales : du tissu sain au cancer

Jean-Damien Combes1 pour Silvia Franceschi1, Christine Clavel2 et Jean Lacau Saint Guily31 International Agency for Research on Cancer, Lyon, France2 INSERM UMR-S 903 / Université de Reims Champagne-Ardenne / CHU Reims, Laboratoire Pol-Bouin, Reims, France3 Service d'ORL et chirurgie cervico-faciale, Hôpital Tenon AP-HP, Paris, FranceSlide2

Study of human Papillomavirus and precancerous Lesions

In the TonsilSPLIT studyMethods- Cross-sectional study- 20 centres in France (2012-2016)- Tonsillectomy for non-cancer reasons- Gargling specimens before surgery- Detection of infectious agents- Cytological and histological precancerous lesionshttp://split.iarc.fr/Slide3

1. HPV infection in non-cancerous tonsils

2. HPV-induced lesions in the oropharynxSlide4

HPV infection in non-cancerous tonsils

Sample testedAge classM/FTotal

0-14

15-24

25-34

35+

Tonsil brushing

139

169

191

193

314/378692Gargling-899089121/147268

HPV-DNA detection test: Luminex® IARC E7-MPG (21 HPV types) (T. Gheit, M. Tommasino)

4Slide5

HPV infection in non-cancerous tonsils

SPLIT study final results (submitted)HPV DNA detection test: IARC E7-MPG platformSlide6

HPV infection in non-cancerous tonsils,by age class and sex (gargle)

SPLIT study final results (submitted)HPV DNA detection test: IARC E7-MPG platformSlide7

HPV infection in non-cancerous tonsils,HPV types

SPLIT study final results (submitted)HPV DNA detection test: IARC E7-MPG platformSlide8

HPV infection in non-cancerous tonsils,concordance Gargle/Tonsil brushing

SPLIT study final results (submitted)HPV DNA detection test: IARC E7-MPG platformSlide9

1. HPV infection in non-cancerous tonsils

2. HPV-induced lesions in the oropharynxSlide10

HPV-induced lesions in

the tonsil (cytology)Slide11

HPV-induced lesions in the tonsil (cytology)

Uninterpretable cytology: many clustered lymphocytes hiding epithelial cells

Uninterpretable

 

cytology

:

low

cellularitySlide12

HPV-induced lesions in the tonsil (cytology)

PMID: 26111735Slide13

HPV-induced lesions in the

tonsil (histology)Slide14

ConclusionsPrevalence of tonsillar HPV infection is overestimated using garglingPoor concordance between HPV detection by gargle and tonsil brushing

Limited prospect for early detection of precancerous lesion in the tonsils HPV-induced tonsillar precancerous lesions?Slide15

AcknowledgementCoordination méthodologie : Jean-Damien Combes (CIRC) et Véronique Dalstein (Reims)

Coordination anatomo-pathologie : Philippe Birembaut (Reims) et Marine Lefèvre (Tenon)Coordination biologie moléculaire : Alain Jung (Paul Strauss Strasbourg) et Christine Clavel (Reims)Coordination épidémiologie et statistiques : Gary Clifford (CIRC) et Silvia Franceschi (CIRC)Coordination chirurgie : Jean Lacau Saint Guily (Tenon)  Chirurgie ORL : Olivier Mauvais et Jean-Michel Badet (Besançon), Emmanuel Babin (Caen), Christian Righini (Grenoble), Justine Lerat (Limoges), Philippe Céruse et Alain Cosmidis (Lyon), Renaud Garel (Montpellier), Olivier Malard (Nantes), Benjamin Lallemant (Nîmes), Nicolas Leboulanger (Trousseau, Necker), Christine Bach (Foch), Sébastien Albert et Beatrix Barry (Bichat), Vincent Couloigner (Necker), Natacha Teissier et Thierry Van Den Abeele (Debré), Bertrand Baujat, Olivier de Crouy Chanel, Maria Lesnik et Sophie Périé (Tenon), Xavier Dufour (Poitiers), Jean-Claude Mérol (Reims), Philippe Schultz (Strasbourg), Sébastien Vergez (Toulouse), Sylvain Morinière (Tours). Anatomo-pathologie : Elisabeth Brambilla (Grenoble), Béma Coulibaly (Limoges), Françoise Berger (Lyon), Elisabeth Cassagnau (Nantes), Heliette Chapuis (Nîmes), Dibor Niang et Aurore Coulomb (Trousseau), Isabelle Wagner (Foch), Louise Galmiche-Rolland (Necker), Dominique Berrebi (Debré), Alexandra Traverse-Glehen (Lyon), Isabelle Brocheriou (Tenon), Pierre Levillain et Eric Frouin (Poitiers), Marie-Danièle Diebold (Reims), Mihaela Onea (Strasbourg), Emmanuelle

Uro-Coste (Toulouse).Anatomo-pathologie SPLIT Lésions précancéreuses : Yves Denoux (Foch), Muriel Hourseau (Bichat), Emmanuèle

Lechapt

(Caen), Cécilia Rousselot-Denis (Tours), Valérie Costes (Montpellier), Séverine

Degano-Valmary

(

Besançon).

 

Biologie

 : Tarik Gheit et Massimo Tommasino (CIRC), Christiane

Mougin et Jean-Luc Prétet (Besançon), Roger Lacave et Patrick Soussan (Tenon), Brigitte Autran et Ghislaine Carcelain (Pitié), Gérard Agius et Agnès Beby-Defaux (Poitiers), Joseph Abecassis (Paul Strauss Strasbourg).Financement PAIR-VADS 2011 – Fondation ARC / INCa / Ligue contre le cancer