PPT-Effects of Glycomacropeptide, Amino Acid & Casein Diets on Osteopenia in PKU Mice
Author : luanne-stotts | Published Date : 2019-03-16
Denise M Ney PhD RD Professor of Nutritional Sciences Waisman Center University of WisconsinMadison Disclosure D Ney is a coinventor on US Patent Application
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Effects of Glycomacropeptide, Amino Acid & Casein Diets on Osteopenia in PKU Mice: Transcript
Denise M Ney PhD RD Professor of Nutritional Sciences Waisman Center University of WisconsinMadison Disclosure D Ney is a coinventor on US Patent Application US20100317597 GMP Medical Foods for Nutritional Management of PKU which is held by the Wisconsin Alumni Research Foundation and licensed to . Extraction. “Securing . Glycomacropeptide. and Casein Curd using GMP manufacture . from skim milk. ”. By Annette Bentley, MS Food Science 2013 & MS Medical Science 2003. Food Technology Conference 2014 . Proteins . Part I. IUG. , 2015. Dr. . Tarek. . Zaida. 1. 2. Background. 3. 4. Casein. MW. Kd. Phosphate groups/molecule. α. 27.3 . 9. β. 24.1. 4-5. κ. 8.0. 2. 5. Casein can be precipitated by:. 1. Calcium ions. By: Adrienne Gebele. What is PKU?. 1. Inherited disorder. Occurrence varied due to ethnicity and geography. About 1 and 10,000 to 15,000 infants are born with in the U.S.. People born with PKU have an inactive liver enzyme which causes a dangerous build up of phenylalanine in the blood. Extraction. “Securing . Glycomacropeptide. and Casein Curd using GMP manufacture . from skim milk. ”. By Annette Bentley, MS Food Science 2013 & MS Medical Science 2003. Food Technology Conference 2014 . By Kevin Zhu, Walter Chen, and. Sachin Patro. Definition. Phenylketonuria (PKU) is a genetic disorder that is described by an lack of ability of the body to use the necessary amino acid called phenylalanine. Amino acids are the building blocks for body’s proteins. 'Essential' amino acids can only be attained from the food that we eat. Our body does not normally produce them. The 'classic PKU', the enzyme that breaks down phenylalanine hydroxylase, is absolutely or almost completely lacking. This enzyme normally turns phenylalanine to another amino acid called tyrosine. Without this ‘Classic PKU', phenylalanine and it’s other breakdown chemicals from other enzyme method, build up in the blood and body tissues. . Richard D. Howells, PhD. Dental Biochemistry Lecture 25 . 2. Learning Objectives. To distinguish between phenylketonuria (PKU) caused by phenylalanine hydroxylase (PAH) defect and PKU caused by defect in . Dr.. . Zaffar. . Mehmood. Definitions:. Food: . means . a raw, cooked, or processed edible substance, ice, beverage, or ingredient used or intended for use or for sale in whole or in part for human consumption, or chewing . . are organic molecules that are the building block of . . proteins. .. -There is 20 . α. -amino acids commonly found in . proteins. . ( . they . have a carboxyl group and an amino group . . . Ahmed Hammam. Lloyd . Metzger. 0.1 - 10.0 . m. 0.01 - 0.1 . m. 0.001 - 0.01 . m. <0.001 . m. Bacteria. UF. NF. RO. Lactose. Minerals. Water. MF. Whey Protein. Fat. 10,000 Daltons. 1,000 Daltons. 50 Daltons. VBC-607. Unit-I. P.G.. 31.10.2020. DEFECT. . IN. . AMINO. . ACID. . CATABOLISM. Phenylketonuria. Deficiency of phenylalanine hydroxylase or a defect in biosynthesis/ reduction of . tetrahidrobiopterin. Peptide bond formation. : . α-carboxyl group of one amino acid (with side chain R1) forms a covalent peptide bond with α-amino group of another amino acid . ( . with the side chain R2) by removal of a molecule of water. The result is : Dipeptide ( i.e. Two amino acids linked by one peptide bond). By the same way, the dipeptide can then forms a second peptide bond with a third amino acid (with side chain R3) to give . porous, brittle . or fragile, which increases the risk of . fracture. Both . men and women can get . o. steopenia. , . particularly after . menopause women . are at higher . risk. [1] . INTRODUCTION. Daum LT, Canas LC, Smith CB, Klimov A, Huff W, Barnes W, et al. Genetic and Antigenic Analysis of the First A/New Caledonia/20/99-like H1N1 Influenza Isolates Reported in the Americas. Emerg Infect Dis. 2002;8(4):408-412. https://doi.org/10.3201/eid0804.010311. Supervised by: Dr. . Nuhad. . Alduri. . Prepared by : . zahraa. . basim. . mohammed. Phenylketonuria. Phenylketonuria, an inborn error of metabolism inherited as an autosomal recessive trait (the PAH gene is located on chromosome 12q24), is caused by a deficiency or absence of the enzyme needed to metabolize the essential amino acid phenylalanine. Classic PKU is at one end of a spectrum of conditions known as .
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