PPT-Evolution of new protein topologies through multistep gene

Sergio G Peisajovich Liat Rockah amp Dan S Tawfik Introduction Protein Folds Protein folding  is the process by which a protein structure assumes its functional shape or conformation It is the physical process by which a polypeptide folds into its characteristic and functional threedimensional structure from random coil. Shantanu. . Dutt. Univ. of Illinois at Chicago. Acknowledgement. Adapted from Chapter 2 slides of the text, by A. . Grama. w/ a few changes and augmentations. Interconnection Networks . for Parallel Computers . Marcus Chibucos, Ph.D.. University of Maryland School of Medicine. June 2014. Overview & goals. Understand. 1. How we predict . presence & structure . of coding & non-coding genes in the genome. Costin. . Raiciu. , . Sebastien. . Barre. , Christopher . Pluntke. , . Adam . Greenhalgh. , Damon . Wischik. , Mark Handley. SIGCOMM 2011. Presented by Anand Iyer. (Most slides borrowed from . Costin’s. Ben Spoerlein. Resident Assistant. Ball State University. Muncie, IN. Charles Darwin. (February 12. th. , 1809 – April 19. th. , 1882). Credited with providing the first convincing evidence for the theory of evolution in his immortal work, . CONSTITUTIVE GENE PRODUCTS ARE NEEDED BY THE BODY AT ALL TIMES. TUMOR SUPRESSOR PROTEINS. ATP. ENZYMES THAT CONTROL CELLULAR RESPIRATION. ADAPTIVE GENE PRODUCTS ARE ONLY REQUIRED UNDER CERTAIN CONDITIONS. Tonya C. Bates. Erin Dolan. Meredith S. Norris. John Rose. Tarren Shaw. Suann Yang. Ron Zimmerman. Facilitators: Kelly Hogan and Jennifer Warner. Gene Expression. Topic: Genetic Regulation. Context: Large lecture section of introductory biology students . Catherine Rendell and Sharon Korek. Welcome . to the GDL. GDL. Semester A. Semester A. Semester B. Semester B. QA Context. Expected QA . Processes. Chickering. . and . Gamson. No . Compromise. Enhance . Lesson 1. What is a network?. Networking Topologies. Be familiar with and can explain the need for computer networks. Describe network topologies in particular start & mesh. Identify obvious strengths and weaknesses of these topologies. DARWIN’S UNDERSTANDING VS. PRESENT DAY. How are inheritable traits passed?. How do variations appear?. Today’s understanding of genes, DNA, variation, and mutations is central to our understanding of how evolution works . Mechanisms of concerted evolution. Unequal cross-over. Gene conversion: non-reciprocal transfer of information between homologous sequences; the main mechanism invoked to explain concerted evolution. Summary of Research Interests. Gene identification and genome annotation. The evolution of genome-sequence compositional properties. Models of protein evolution. The phylogeny of Bacteria. Measures of differentiation from genomic and . Controlling gene expression is often accomplished by controlling transcription initiation.. Regulatory proteins . bind to DNA to either block or stimulate transcription, depending on how they interact with RNA polymerase.. A trait that improves a population’s reproductive success is . an adaptation. .. An individual/population that is . adapted. is successful at producing grandchildren in its environment.. Adaptation. lacZ . b. -galactosidase histochemical test yes animal. GUS. . b. -glucuronidase histochemical test yes plant. GFP Green Fluorescent Protein fluorescence no animal/plant.