PPT-An Overview of Gene Structure & Function Prediction

Marcus Chibucos PhD University of Maryland School of Medicine June 2014 Overview amp goals Understand 1 How we predict presence amp structure of coding amp noncoding genes in the genome. Why do we want to know protein structure?. Classification. Functional Prediction. What is protein structure?. Primary - chains of amino acids. Secondary - interaction between groups of amino acids. Tertiary - the organization in three dimensions of all the atoms in a polypeptide. Elad. . Hazan. (. Technion. ). Satyen Kale . (Yahoo! Labs). Shai. . Shalev-Shwartz. (Hebrew University). Three Prediction Problems: . I. Online Collaborative Filtering. Users: . {1, 2, …, m}. Movies: . Winston P. Nagan . With the assistance of Megan E. Weeren . April 10, 2015. Anticipation will invariably entail complexity in the context of the individual self systems functioning in the social process and interacting in social relations.. Debajit. B. h. attacharya. Ali . JavadiAbhari. ELE 475 Final Project. 9. th. May, 2012. Motivation. Branch Prediction. Simulation Setup & Testing Methodology. Dynamic Branch Prediction. Single Bit Saturating Counter. Cell/Developmental Biology I. Group Members. Kelly Hogan, Facilitator . Rita Graze. Matthew . Kearley. . Zheng-Hua. Ye. Xiaoyu. Zhang. Christine Sestero. Heather Tinsley. Learning Goal: . Understand . Data. Lijing Wang. 1. , . Yangzhong. . Tang. 2. , . Stevan. . Djakovic. 2. , . Julie . Rice. 2. , . Tony . Wu. 2. , . Daniel J. . Anderson. 2. , . Yuan . Yao. 3. DahShu. Data Science Symposium: Computational Precision Health . Objectives. To better understand variability in eastern upwelling regions and the Gulf of Guinea. To enhance climate modelling and prediction capabilities. Improve understanding of marine ecosystems for better prediction and management. Draw 8 boxes on your paper. Gene regulation accounts for some of the phenotypic differences between organisms with similar genes.. 2005-2006. Gene regulation in bacteria. Control of gene expression enables individual bacteria to adjust their metabolism to environmental change. Advisor: Dr. Chen . Keasar. Arie Barsky, Nadav Nuni. Protein folding problem. Proteins are responsible for constructing and operating the organism, and are made of chains of amino-acids. Protein folding problem. Section 1: Introduction and biological databases.. Section 2: Sequence alignment.. Section 3: Gene and promoter prediction.. Section 4: Molecular phylogenetics.. Section 5: Structural Bioinformatics. VBC-603. P.G.. 30.12.2020. Protein . Strucuture. Sequence, Structure and Function. What determines fold?. Anfinsen’s experiments in 1957 demonstrated that proteins can fold spontaneously into their native conformations under physiological conditions. This implies that primary structure does indeed determine folding or 3-D . An imaginary overview . All information of our life is written in two Books . . Two set (23 Pairs) of Chromosomes . One of these Books of life is written by Father. Set of chromosomes (23) inherited from Father. Rikky. . Wenang. . Purbojati. miRNA. MicroRNA. (miRNA) is a class of RNA which is . believed to play important roles in gene regulation.. It’s a . short (21- to 23-nt) RNAs that bind to the 3′ . Some of the slides are adapted from Dr. Dong Xu’s lecture notes. Why secondary structure prediction?. Accurate secondary structure prediction can be an important information for the tertiary structure prediction.