Dr Sobia Ibrahim Assistant Professor Anatomy KEMU Saliva is produced by Three major salivary glands Parotid Submandibular Sublingual Numerous minor salivary glands Saliva is a hypotonic watery secretion ID: 558481
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HISTOLOGY OF SALIVARY GLANDS
Dr. Sobia Ibrahim
Assistant Professor Anatomy,
KEMUSlide2
Saliva is produced by
Three major salivary glands
Parotid
Submandibular
Sublingual
Numerous minor salivary glandsSlide3
Saliva is a hypotonic watery secretion
It contains
mucous,
Enzymes,
Secretory antibodies,
Inorganic salts.
Daily production is 600-1500ml in humanSlide4
GENERAL STRUCTURE OF SALIVARY GLANDS
STROMA
Capsule
Septa
Blood vessels & nerves
Ducts
Lobule
PARENCHYMA
Accini
Duct systemSlide5
Each gland is surrounded by a connective tissue capsule
From capsules, multiple septae are thrown inwards to divide the parenchyma into incomplete lobules
Within each lobule many secretory
acini are surrounded by fine loose C.T .
Blood vessels, lymphatic vessels, nerves and excretory ducts travel through septa.Slide6
PARENCHYMA
Glands are
tubuloacinar variety
Acini consists of secretory cells which have a lumen in middle going to
duct
Serous
, mucous
or mix.
Myoepithelial
cells lie between plasmalemma and basal lamina of secretory cellsSlide7
MUCOUS & SEROUS ACCINISlide8
DUCT SYSTEM
INTERCALATED DUCTS
Lined by cuboidal epithelium
STRIATED DUCT
Lined by columnar cells
& show Radial striations
INTERLOBULAR/
EXCRETORY DUCTS-
in
CT septa
Proximally- pseudostratified/stratified cuboidal
Distally – stratified columnar
MAIN DUCT
Non keratinized stratified
squamous epitheliumSlide9
PAROTID GLAND
BRANCHED ACCINAR gland
SEROUS
Striated & intercalated ducts in parenchyma
Interlobular duct in CT septa
Plasma cells present in CT septa
Secretory products has:
Amylase
Proline
- rich
protien which has calcium binding properties Slide10
SUBMANDIBULAR GLAND
BRANCHED TUBULOACCINAR gland
Predominantly SEROUS
Majority serous
accini
Mucous
accini
with serous demilunes-10%
Well developed striated ducts
Underdeveloped intercalated ducts
Secretory products have:
Amylase
Proline
rich
protiens
Lysozymes Slide11
SUBLINGUAL GLAND
BRANCHED TUBULOACCINAR gland
Predominantly mucous
Serous cells only as
demilunes
Striated & intercalated ducts
not
well developed
Secretory products :
Amylase
Lysozymes Slide12
COMPARISONSlide13
MINOR SALIVARY GLANDS
Scattered throughout oral mucosa &
submucosa
Nonencapsulated
Usually MUCOUS
Exception is von Ebner gland of tongue
Short ducts open on oral mucosa
B
lynmphocytes
releasing IgA commonSlide14
MEDICAL APPLICATION
Reduced function of major salivary glands due to disease / radiotherapy
RESULTS:
Caries
Atrophy of oral mucosa
Speech difficulties Slide15
SEROUS CELL
Pyramidal cells
.
Broad
end facing the basement membrane and narrow end facing lumen.
6-8 in no
.
Apex has microvilli
Basal region has rounded nucleus
.Basal region have abundant RER (due to which basal region stain basophilic)and mitochondria.Apical region : zymogen (secretory) granules ,so apical region is acidophilic
Adjacent serous cell joined by junction near apices.Intercellular canaliculiFUNCTION: thin and watery secretionsSlide16
MUCOUS CELL
Tall cuboidal or low columnar
cells with basal flattened nuclei.
Apical region has
mucinogen
granules.
H&E stain mucous poorly so
muous
cells appear empty.
Well developed golgi apparatus.E/M: junctional complexes, no intercellular canaliculi
.Cells secrete mucinogen which on contact with water form mucous.