PPT-Oxidative Phosphorylation

Pratt and Cornely Chapter 15 Goal ATP Synthesis Overview Redox reactions Electron transport chain Proton gradient ATP synthesis Shuttles Standard Reduction Potential potential to be reduced. ABSTRACT Oxidative stress is increased in diabetic patients since persistent hyperglycemia causes an increased production of oxygen free radicals through autoxidation of glucose and non enzymatic gl ycation of proteins Increased levels of the produc to proteins in . Drosophila . melanogaster. Trevor Short. Dr. David Brown, Faculty Advisor. Previous research has suggested that there is a link between an accumulation of oxidative damage and aging [1, 2, 3, 4]. Oxidative damage occurs as a result of the inability of the body to detoxify reactive oxygen species that are generated in the body as a byproduct of cellular respiration; These reactive oxygen species may go on to react with proteins in the body and inhibit their ability to function normally [4, 5]. When a reactive oxygen species interacts with a protein, amino acid residues are converted to carbonyl groups [4,5]. This experiment was performed in fruit flies. Ken Wu. Disclaimer. This tutorial is a simple and conceptual guide to metabolism. If there are any conflicts between my slides and the lecturers, . THE LECTURER IS ALWAYS RIGHT…. …maybe not always but they set your exams so if in doubt, refer back to their teaching. Abishek Santhakumar, PhD. Lecturer & Course-coordinator - Pathology. School of Medical and Applied Sciences. Overview . . Introduction. Platelet activity & Thrombosis. Aim. Methodology. Study overview. & . Elimination. Dr. Sandro Percario. Editorial . Board Member. Professor. Ph.D., Federal University of . Para, Brazil. Guest Researcher. US Centers for Disease Control and Prevention, . USA. .. +. -K. +. Pump: . A . Functionally Relevant Circulating Marker of Oxidative . Stress. Dr. Chia-chi Liu. Molecular Cardiac Research Unit . Sydney Medical School . University of Sydney. . Australia. Outline. Oxidative Stress. O. 2. is readily reduced to form one of many Reactive Oxygen Species (ROS) . ROS cause cellular damage. DNA. Protein. Lipids. http://www.vivo.colostate.edu/hbooks/pathphys/misc_topics/ros.gif. The flow of electrons from NADH and FADH. 2. to O. 2. occurs in the electron-transport chain or respiratory chain.. This exergonic set of oxidation–reduction reactions generates a proton gradient.. Chapter 26, . Stryer. Short Course. Glucose Metabolism Overview. Gluconeogenesis. Glycogen . metabolism. Pentose Phosphate Pathway. Pentose Phosphate Pathway. Dual Purpose. Synthesis of “reducing potential”. P. hosphorylation. Sites to. . K. inases. . by Conditional Random Fields. --- . CS 104 Project. Lu He, . Tuobin. . W. ang . Background and Problem. Problem: . Given . groups of . kinases. Simultaneous introduction of a pair of anionic ligands, A and B, of an A−B molecule such as H. 2. or CH. 3. ‐I. . A−B bond is broken, and M−A and M−B bonds are formed. . ▪. The oxidation state (OS), electron count (EC), and coordination number (CN) all increase by two units during the reaction.. Anju. .M.P. BCH.10.05.12. One of the paradoxes of life on this planet is that the molecule that sustains aerobic life, oxygen, is not only fundamentally essential for energy metabolism and respiration, but it has been implicated in many diseases and degenerative conditions. 1 | 7:39998 | DOI: 10.1038/srep39998 www.nature.com/scientificreports 2 domain and the GDI-like domain sandwich actin, triggering YopO autophosphorylation and the allosteric stabilization of the acti (mitochondria and . peroxisomes. ). Dr. Mamoun Ahram. Faculty of Medicine. Second year, Second semester, 2014-2014. Principles of Genetics and Molecular Biology. What are the mitochondria?. Mitochondria are thought to have evolved from bacteria via .