PPT-Oxidative Phosphorylation

Pratt and Cornely Chapter 15 Goal ATP Synthesis Overview Redox reactions Electron transport chain Proton gradient ATP synthesis Shuttles Analogy How does burning coal put flour in the grocery store. to proteins in . Drosophila . melanogaster. Trevor Short. Dr. David Brown, Faculty Advisor. Previous research has suggested that there is a link between an accumulation of oxidative damage and aging [1, 2, 3, 4]. Oxidative damage occurs as a result of the inability of the body to detoxify reactive oxygen species that are generated in the body as a byproduct of cellular respiration; These reactive oxygen species may go on to react with proteins in the body and inhibit their ability to function normally [4, 5]. When a reactive oxygen species interacts with a protein, amino acid residues are converted to carbonyl groups [4,5]. This experiment was performed in fruit flies. +. -K. +. Pump: . A . Functionally Relevant Circulating Marker of Oxidative . Stress. Dr. Chia-chi Liu. Molecular Cardiac Research Unit . Sydney Medical School . University of Sydney. . Australia. Outline. to proteins in . Drosophila . melanogaster. Trevor Short. Dr. David Brown, Faculty Advisor. Previous research has suggested that there is a link between an accumulation of oxidative damage and aging [1, 2, 3, 4]. Oxidative damage occurs as a result of the inability of the body to detoxify reactive oxygen species that are generated in the body as a byproduct of cellular respiration; These reactive oxygen species may go on to react with proteins in the body and inhibit their ability to function normally [4, 5]. When a reactive oxygen species interacts with a protein, amino acid residues are converted to carbonyl groups [4,5]. This experiment was performed in fruit flies. Oxidative Stress. O. 2. is readily reduced to form one of many Reactive Oxygen Species (ROS) . ROS cause cellular damage. DNA. Protein. Lipids. http://www.vivo.colostate.edu/hbooks/pathphys/misc_topics/ros.gif. The flow of electrons from NADH and FADH. 2. to O. 2. occurs in the electron-transport chain or respiratory chain.. This exergonic set of oxidation–reduction reactions generates a proton gradient.. Pratt and . Cornely. , Chapter 15. Goal: ATP Synthesis . Overview. Redox reactions. Electron transport chain. Proton gradient. ATP synthesis. Shuttles. Standard Reduction Potential. “potential to be reduced”. P. hosphorylation. Sites to. . K. inases. . by Conditional Random Fields. --- . CS 104 Project. Lu He, . Tuobin. . W. ang . Background and Problem. Problem: . Given . groups of . kinases. Anju. .M.P. BCH.10.05.12. One of the paradoxes of life on this planet is that the molecule that sustains aerobic life, oxygen, is not only fundamentally essential for energy metabolism and respiration, but it has been implicated in many diseases and degenerative conditions. 1 | 7:39998 | DOI: 10.1038/srep39998 www.nature.com/scientificreports 2 domain and the GDI-like domain sandwich actin, triggering YopO autophosphorylation and the allosteric stabilization of the acti Objectives: Oxidative Decarboxylation. By the end of this lecture, students are expected to:. Recognize the various fates of pyruvate. Define the conversion of pyruvate to acetyl CoA. Discuss the major regulatory mechanisms for PDH complex. (mitochondria and . peroxisomes. ). Dr. Mamoun Ahram. Faculty of Medicine. Second year, Second semester, 2014-2014. Principles of Genetics and Molecular Biology. What are the mitochondria?. Mitochondria are thought to have evolved from bacteria via . Citric Acid Cycle. Only a Small Amount of Energy Available in Glucose is Captured in Glycolysis. 2. G’° = -146 kJ/mol. Glycolysis. Full oxidation (+ 6 O. 2. ). G’° = -2,840 kJ/mol. 6 CO. 2. 4. ) group to a protein or other organic molecule.. Phosphorylation. activates or deactivates many protein enzymes, estimated that as much as half of all cellular proteins can be . phosphorylated. . Olsen Science . Signaling 3 (2010). Protein . phosphorylation. . and . dephosphorylation. are highly controlled biochemical processes that respond to various intracellular and extracellular stimuli. .