PPT-Precision Medicine Clinical Trial Designs

2018 AACR Annual Meeting April 15 2018 Edward Chu MD UPMC Hillman Cancer Center University of Pittsburgh School of Medicine Drug A Time years Percent One Size Fits All Approach. 1 02 03 04 05 06 07 08 09 1 Measured Value of x Fraction of Total Measurements SD 01 SD 02 SD 03 brPage 5br mean standard deviation histogram Figure 3 Mass of Unknown Sample 102 104 106 108 11 112 114 116 118 12 Mass kg of Measurements brPage 6br Anh Ninh, College of William and Mary. Outline. Introduction. The Inventory Positioning Problem. Description of the problem. Unique features. Basic of inventory management. Site Selection Problem. 2. From Promise to Practice. PRECISION ONCOLOGY IS THE FUTURE OF CANCER CARE.. Tumor genome data informs cancer treatment and clinical pathways, resulting in better health outcomes.. New cancer therapies target the molecular pathways that lead to tumor genesis and progression.. Define: . Accuracy. Precision. Draw & . Label. 4 dart boards to illustrate:. . (. each board should contain . 4 marks. ). High Accuracy, High Precision. High Accuracy, Low Precision. Low Accuracy, High Precision. Anh Ninh, College of William and Mary. Outline. Introduction. The Inventory Positioning Problem. Description of the problem. Unique features. Basic of inventory management. Site Selection Problem. 2. The Balance from . A Medical Communicator’s Perspective. 6th Asia-Pacific . Pharma. Congress. July 11-13, 2016 Kuala Lumpur, Malaysia. Dr.Namrata. Singh. Director - Medical Services. Turcaoz. Health Care Solutions. 1. 2015 Precision Medicine Initiative: . Two Components: Cancer & National Cohort. “. An emerging approach for disease prevention and treatment that takes into account people’s individual variations in genes, environment, and lifestyle”. Jeremy Warner . MD, MS. Assistant Professor of Medicine and Biomedical . Informatics. Vanderbilt University. June 26, 2017. Three questions every cancer patient asks. Who’s like me?. How long have I got?. Part 2. Resident and Fellows Lecture Series. A. pril 12, 2016. Elizabeth Garrett-Mayer, . PhD. Hollings Cancer . Center. . Current State of Phase II. Lots of changes in the past several years. Phase I . CLINICAL TRIALS IN THE TWENTY-FIRST CENTURY: ONGOING CHALLENGES AND EMERGING ISSUES Susan S. Ellenberg , Ph.D. University of Pennsylvania SCT/ICTMC Joint Meeting Liverpool, UK May 8, 2017 CLINICAL TRIALS TIMELINE IV External Validity T. he . trial sponsor . compiles . a detailed clinical study report (CSR. ) after each clinical trial. . This report follows . a format laid down by the regulatory . authorities.. The CSR can be hundreds of pages long.. Karen L. Edwards, . PhD. Professor, Dept. of Epidemiology. School of Medicine. University of . California, Irvine. Irvine, CA. Outline. Two National Initiatives . Precision Medicine Initiative . Cancer . Owen Tan. 1. , Deborah Schofield. 1. , Rupendra Shrestha. 1. 1. GenIMPACT: Centre for Economic Impacts of Genomic Medicine, Macquarie Business School, Macquarie University, Australia.. Presenting at: .