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The Role of MRD in Hematologic Malignancies The Role of MRD in Hematologic Malignancies

The Role of MRD in Hematologic Malignancies - PowerPoint Presentation

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Uploaded On 2016-05-27

The Role of MRD in Hematologic Malignancies - PPT Presentation

Educational Objectives Minimal Residual Disease Flow Cytometry MRD Sensitivity Using Flow Cytometry By Disease State Genetic Methods for MRD Quantification AlleleSpecific Oligonucleotide ASOPCR ID: 337025

methods mrd references outcomes mrd methods outcomes references aall0232 assessment pcr flow disease aso sequencing cont malignancies generation role

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Presentation Transcript

Slide1

The Role of MRD in Hematologic MalignanciesSlide2

Educational ObjectivesSlide3

Minimal Residual DiseaseSlide4

Flow CytometrySlide5

MRD Sensitivity Using Flow CytometryBy Disease StateSlide6

Genetic Methods for MRD QuantificationSlide7

Allele-Specific Oligonucleotide (ASO)-PCRSlide8

MRD Methods – Next Generation SequencingSlide9

MRD Methods – Next Generation SequencingSlide10

ASO-PCR vs NGSSlide11
Slide12

Comparison of MRD Assessment ApproachesSlide13

Current Role of MRD Assessment in Clinical CareSlide14

MRD in Acute Lymphoblastic Leukemia

Children’s Oncology Group AALL0232Slide15

COG AALL0232: OutcomesSlide16
Slide17
Slide18

ALL: Outcomes by Quantitative MRD RangesSlide19

MRD Following HCT in ALLSlide20
Slide21

Post Transplant MRD in CLLSlide22
Slide23

MRD and Outcomes in MMSlide24

MRD in Non-Hodgkin LymphomaSlide25
Slide26
Slide27

Summary of MRD in Lymphoid MalignanciesSlide28

Future Perspectives in MRDSlide29

AbbreviationsSlide30

ReferencesSlide31

References (cont)Slide32

References (cont)