PPT-Agonist-Antagonist discrimination: a pseudo-semantic approach to Molecular Dynamics

Anna Maria Nardiello 1 Lucia Sessa 12 Jacopo Santoro 1 and Stefano Piotto 12 1 Department of Pharmacy University of Salerno Fisciano 84084 Italy 2 Research Centre for . W. ith much content shamelessly pilfered from Dr. . DeFranco’s. lecture slides on . pharmacogenetics. ….. Jennifer Hu. CoSBBI. , July 12 2013 . A few questions to get us started…. What is pharmacogenomics?. Protagonist. The main character of the story or drama, the hero, who is faced with an opposing force to overcome in order to achieve a goal. Give some examples of a protagonist. Nemo. -. Finding . Nemo. Teaser. Zak Fallows. 2013-07-03. http://datb.mit.edu. pharmacology@mit.edu. 1. How the Brain Works. You have about 100 billion brain cells, which are called neurons.. Each neuron has about 1,000 connections, called synapses. (This number is extremely variable.). A New Family of Replacement Policies for Last-level Caches. Mainak. . Chaudhuri. Indian Institute of Technology, Kanpur. Agenda. Prolog. Configurations and Workloads. Fill Stack Order. Observations. Daniel Trugman. , July . 2013. 2D Rough-Fault Dynamic Simulations. Homogenous background stress + complex fault geometry . . heterogeneity in tractions. Eliminates important source of uncertainty: fault geometry is a direct observable. Denise Chac. 10 October 2014. Immunology. The study of the human immune system . Lymphocytes. B Cells. Membrane bound antibody. Activation: bind to pathogen and triggered by helper T cells. MHC II proteins present antigen peptide on cell surface. Yu-Shan . Lin (YSL). Department of . Chemistry. Tufts . University. Simulate how molecules move. Molecular dynamics simulations. km. hr. v. . (0). = . =. . 100. = 1000 kg. = . −. 7000 N. m. s. 2. Lesson 7. Quick Re-cap. What is the anatomical position?. What are 3 examples of types of movement?. What is another term used for Agonist?. Define Agonist or ________?. Define Antagonist. What type of joint is your shoulder?. Empty follicles. Woman following GnRH agonist protocol. During egg collection follicles seem empty (no COCs) . Blood sample – low levels of HCG. Abandon procedure, trigger again and proceed to new oocyte retrieval . Physics 5403: Computational Physics. Physics. 5403: . Computational. . Physics. - . Chapter. 6: . Molecular. Dynamics. 1. 6.0 Overview. What is molecular dynamics (MD)?. Numerical method for studying many-particle systems such as molecules, clusters, and even macroscopic systems such as gases, liquids and solids . autocoids. ) or local hormones are substances produced by different tissues throughout the body . and . act locally . in . brief duration . to . modulate the activity of smooth muscles, . nerves, . platelets, and other tissues. Several autacoids also serve as neurotransmitters in the central nervous system (CNS) or enteric nervous system. . Objectives. Discuss the pharmacology of . catecholamines. Classify & describe adrenergic α-agonists including actions, therapeutic uses & adverse. reactions.. Classify & describe adrenergic β-agonists including actions, therapeutic uses & adverse. Graded Dose-response . Relationships:. Agonist drugs mimic the action of the original endogenous ligand for the receptor (for example, isoproterenol mimics norepinephrine on β1 receptors of the heart). . muscarinic. antagonist / . muscarinic. blocker.. OBJECTIVES. Classify & describe cholinergic antagonists. Explain actions, therapeutic uses & adverse reactions of cholinergic antagonists. Cholinergic antagonist / Cholinergic blockers.