PPT-The Breast Cancer Epidemic: Evidence for a

R adiogenic C ause Christopher Busby Environmental Research SIA Riga Latvia European Committee on Radiation Risk ECRR Brussels Cancer is a genetic disease expressed at the cellular level More than 80 of all cancers are the result of damage to genetic material from environmental carcinogens Other components of risk are inherited genetic predispositions which themselves may be environmental in origin. Chief, Division of Environmental Health. Senior Toxicologist . Illinois Department of Public Health. Breast Cancer &. Environmental Exposures. Carcinogens. Definition:. Substances & exposures that lead to cancer. Diana Sarfati. Director, Cancer Control and Screening Research Group. Breast cancer. Most common cancer for women in NZ . 600 women die each year from breast cancer. Trends . in age standardized I. ncidence . Chief, Division of Environmental Health. Senior Toxicologist . Illinois Department of Public Health. Breast Cancer &. Environmental Exposures. Carcinogens. Definition:. Substances & exposures that lead to cancer. October 25,2017. Disclosures. None. Outline. Epidemiology. Risk Factors. Screening. Diagnosis. Treatment. Genetic testing. Research. Epidemiology. 2017 :estimated 252.710 new cases of invasive breast cancer in women. {Template Slide Set}. 1. Overview. What are Hereditary Breast and Ovarian Cancer syndrome (HBOC) and Lynch . s. yndrome (LS)?. How common are LS and HBOC? . How do LS and HBOC affect individuals and families?. BRCA2 is a tumor suppressor gene responsible for DNA repair . BRCA2 was discovered in breast cancer tumors of patients without BRCA1 mutations. Mice knockouts discovered that BRCA2 is directly involved in double strand break repair. Steven J. Katz MD MPH. Professor of Medicine and Health Management and Policy. University of Michigan . Allison Kurian MD M Sc.. Professor of Medicine and Medical Genetics . Stanford University . Guidelines 2019. Cleveland Clinic Florida. Breast Surgeon . September 25, 2018. Breast Cancer . Highly prevalent disease . Limited to female sex in all but < 1% of cases in USA. SEER . Cancer. . Stat Facts: Female Breast Cancer. Manchester January 2018. Some Musings. POETIC Trial. Multicentre, phase III, randomised trial for post menopausal women with ER/PR positive invasive breast cancer to determine whether 2 weeks of perioperative aromatase inhibitor before and after surgery improves outcome.. Number 37 Genetic Risk Assessment and BRCA Mutation Testing for Breast and Ovarian Cancer Susceptibility: Evidence Synthesis U.S. Department of Health and Human Services Agency for Healthcare Resea U.S. Preventive Services Task Force American Cancer Society American College of Obstetricians and Gynecologists4,5 International Agency for Research on Cancer 7 American College of adiology American Dr. Scott . Klarenbach. MD MSc . Working Group Chair. Use of Slide Deck. These slides are made . available publicly . following the guideline’s release as an educational support to assist with the dissemination, uptake and implementation of the guidelines into primary care practice . March 2019. Preview/Introduction. The Risk of Breast Cancer to Women. Does Mammography Save Lives?. When to Start and How Often Should Women Screen?. Risks Versus Benefits of Mammography. Breast Cancer: The Impact on Women.  breast tissue, . most . commonly from the inner lining . of.  milk ducts or the lobules that supply the . ducts . with . milk.. Breast cancer may be invasive or noninvasive. . Invasive.