PPT-Assembly reflects evolution of protein complexes

Emmanuel D Levy Elisabetta Boeri Erba Carol V Robinson amp Sarah A Teichmann 200888 zhen JC Most proteins interact with other proteins and form protein complexes to carry out their function. IntAct. protein complexes. Sandra Orchard. PRO Meeting. , June 19, 2014. Project aims. Reference resource for macromolecular complexes. Create species-specific stable complex identifiers. Central reference resource to link all related efforts (. Birgit . Meldal. (IntAct). Overview. Aims & Definitions. Data Sources. Issues and Challenges:. Nomenclature. Sets. ‘Transient’ complexes. GO. Confidence scores. Inference. Visualisation. Search Parameters and Filters. Presented by Nathalie . Kirshman. and Xinyi Ma. Background . Protein complexes . TAP (tandem-affinity purification). Background . –. protein complexes. At the biochemical level, proteins rarely act alone; rather, they interact with others to perform cellular tasks. Audry Kang. 7/15/2013. Central Dogma of Molecular Biology. Protein Review. Primary Structure: . Chain of amino acids. Secondary Structures: . Hydrogen bonds resulting in alpha helix, beta sheet and turns. Siew Who Choo et al. 2017. Genome Research. Manis. sp.. Manis. sp.. Rationale. Only mammal who’s skin is covered by large and overlapping keratinized scales. .. Origin of this unique trait is unknown…Perhaps defense armor against predators. Artificial selection increases life span in fruit flies. Inherent limits, or can lifespan evolve?. Fruit fly expt:. Female sockeye salmon defending its nest before dying. II. Fundamental Trade-offs. Mite Kiwi bird. Summary of Research Interests. Gene identification and genome annotation. The evolution of genome-sequence compositional properties. Models of protein evolution. The phylogeny of Bacteria. Measures of differentiation from genomic and . LapA. in LPS Assembly. Aarthi Prakash. December 1, 2017. Lipopolysaccharide. Outer membrane of E. Coli. LPS . 6 Fatty Acyl Side Chains with many sugars attached. LPS bind together. Provides gel like barrier. Question. Why design novel proteins? . what can be gained by the design and characterization of novel proteins? . Can we design 3D protein structures that have never been observed?. Are the 3D structures that have not been observed in nature unattainable, or just . Isshak. . Mrabet. . G-Protein. . coupled. receptors. B2 . adrenergic. receptor. Structural. . Biology. INDEX. Introduction. X-ray. Evolution. Structure . Inverse Agonist. Agonist. Comparisons. Active – inactive . robert.tomko@med.fsu.edu. Proteasome . assembly and . catalysis, protein degradation. High-throughput . screening for novel modulators of proteasome assembly or function. Quality control of . multisubunit. Prediction . Wang Yang. 2014.1.3. Outline. Molecular. . Co-evolution . phenomenon. A. pplications . of Co-evolution . in . protein structure prediction and PPI prediction.. Co-evolution measurement: . Muscular Dystrophy. Genetic disorder . A protein to protect muscle is not created properly. Causes muscles to weaken and break apart over time. Disease Review. Sickle Cell Anemia. Genetic disorder. Mutation in genes causes proteins to . Muscular Dystrophy. Genetic disorder . A protein to protect muscle is not created properly. Causes muscles to weaken and break apart over time. Disease Review. Sickle Cell Anemia. Genetic disorder. Mutation in genes causes proteins to .