Al Parker CBE A quick summary of EPAs Technical Laboratory Workshop Antimicrobial Efficacy Test Methods and Activities February 1819 2014 March 6 2014 Venue Hosted by EPA amp ID: 629343
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Slide1
Center for
Biofilm
Engineering
Al Parker,
CBE
A quick summary of:
EPA’s Technical
Laboratory Workshop: Antimicrobial Efficacy Test Methods and Activities February 18-19, 2014
March 6, 2014Slide2
Venue
:Slide3
Hosted by EPA &
CSPASlide4
Goal: Provide Update on EPA’s test programSlide5
Current EPA methods for product registration
Current EPA
w
ork-horse
is the
semi-quantitative
use-dilution method Slide6
Current EPA
w
ork-horse
is the
semi-quantitative
use-dilution method
Current EPA methods for product registration Slide7
New method for EPA registration
Proposed new EPA
w
ork-horse
is the
quantitative
OECDSlide8
OECD Method
Bactericidal – ongoing
efforts
Mycobactericidal
– collaborative study results
Virucidal – ongoing efforts and plans for a collaborative study
Fungicidal – future efforts
New EPA registration processes:
Other new methods for claims for:
sporicides of C. difficil (
AOAC three step method)antimicrobial
towelettes – ASTM Quantitative Petri Plate Method (QPM)
anti-biofilm products – ASTM Single Tube method (STM)Slide9
A Biofilm claim for surface disinfectants???!!!!
Proposed biofilm organisms to test:
P.
a
eruginosa
S. aureusSlide10
Proposed biofilm test method:
Single Tube Method
A Biofilm claim for surface disinfectants???!!!!Slide11
Proposed testing requirements:
2 orgs
3 tests/org
3-5 reps/test/org
LR
> 5 per test
A Biofilm claim for surface disinfectants???!!!!Slide12
A Biofilm claim for surface disinfectants???!!!!Slide13
CBE
opportunities
ahead:
New contract in place with EPA as of February, 2014
Optimize CDC reactor and Single Tube Method for
S. aureus
Standardize with ASTM EPA’s proposed changes to CDC and Single Tube Methods
Assist with implementation and statistical analysis of future multi-lab studies of proposed new
regulatory methods for:
tuberculocides
C. difficil sporicides
fungicides
v
irucides
a
nti-microbial
towelettes
Statistically assess performance standards (numbers of replicates and
LR
requirements) for proposed methods