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�� Metoprolol tartrate USP is a white, practically odorless, crystalline powder with a molecular weight of 684.82. It is very Inactive Ingredients: Tablets contain cellulose compounds, colloidal silicon dioxide, D&C Red No. 30 aluminum lake (50-mg tablets), FD&C Blue No. 2 aluminum lake (100-mg tablets), lactose, magnesium stearate, polyethylene glycol, propylene glycol, povidone, CLINICAL PHARMACOLOGY ��
The median delay from the onset of symptoms to the initiation of therapy was 8 hours in both the Lopressor-and placebo-treatment serum albumin. Metoprolol is a racemic mixture of R-and S-enantiomers. Less than 5% of an oral dose of Lopressor is recovered ��
Lopressor is contraindicated in patients with a heart rate and third-degree heart block; significant first-degree
WARNINGS Hypertension and Angina Cardiac Failure: Sympathetic stimulation is a vital component supporting circulatory function in congestive heart failure, and beta blockade carries the potential hazard of further depressing myocardial contractility and precipitating more severe In Patients Without a History of Cardiac Failure: Continued depression of the myocardium with beta-blocking agents over a period of time can, in some cases, lead to cardiac failure. At the first sign or symptom of impending cardiac failure, Ischemic Heart Disease: Following abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina Bronchospastic Diseases: PATIENTS WITH BRONCHOSPASTIC DISEASES SHOULD, IN GENERAL, NOT RECEIVE BETA B
LOCKERS, including Lopressor. Because of its relative beta1 selectivity, however, Lopressor may be used with caution in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. 1 selectivity is not absolute, a beta2-stimulating agent should be administered concomitantly, and the lowest possible dose of Lopressor should be used. In these circumstances it would be prudent initially to administer Lopressor in smaller Major Surgery: The necessity or desirability of withdrawing beta-blocking therapy, including Lopressor, prior to major surgery is controversial; the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of Lopressor, like other beta blockers, is a competitive inhibitor of beta-receptor agonists, and its effects can be reversed by administration of such agents, e.g., dobutam
ine or isoproterenol. However, such patients may be subject to protracted severe Diabetes and Hypoglycemia: Lopressor should be used with caution in diabetic patients if a beta-blocking agent is required. Beta blockers may mask tachycardia occurring with hypoglycemia, but other manifestations such as dizziness and sweating Pheochromocytoma: In patients known to have, or suspected of having, a pheochromocytoma, Lopressor is contraindicated (see CONTRAINDICATIONS). If Lopressor is required, it should be given in combination with an alpha blocker, and only Thyrotoxicosis: Beta-adrenergic blockade may mask certain clinical signs (e.g., tachycardia) of hyperthyroidism. Patients suspected of developing thyrotoxicosis should be managed carefully to avoid abrupt withdrawal of beta blockade, which might Myocardial Infarction Cardiac Failure: Sympathetic stimulation is a vital component
supporting circulatory function, and beta blockade carries the potential hazard of depressing myocardial contractility and precipitating or exacerbating minimal cardiac failure. During treatment with Lopressor, the hemodynamic status of the patient should be carefully monitored. If heart failure occurs persists despite appropriate treatment, Lopressor should be discontinued. page 4 of 10 ��
Lopressor slows AV conduction and may produce significant first-(P-R interval ��
Second-or third-degree heart block �� &
#x0000;� Bottles of 100 NDC 0078-0458-05 Bottles of 100 NDC 0078-0459-05 NDC 0078-0459-05 &#x/MCI; 9 ;&#x/MCI; 9 ;Dispense in tight, light-resistant container (USP). &#x/MCI; 10;&#x 000;&#x/MCI; 10;&#x 000;Lopressor&#x/MCI; 11;&#x 000;&#x/MCI; 11;&#x 000;® &#x/MCI; 12;&#x 000;&#x/MCI; 12;&#x 000;Injection metoprolol tartrate injection, USP Ampuls 5 mL – each containing 5 mg of metoprolol tartrate Carton of 10 ampuls NDC 0078-0400-01 ��