PDF-(BOOS)-Regulation and Licensure of Whole Blood and Blood Components

Speakers from the Center for Biologics Evaluation and Research of the Food and Drug administration contributed to the September 2009 public workshop on licensure and thus to the contents of this bookp iii. 1 Prepared by the BCSH Blood Transfusion Task Force Address for correspondence: BCSH Secretary British Society for Haematology 100 White Lion Street London N1 9PF e - mail bcsh@b - s - h.org.uk Writi Why we should not use whole blood. Whole blood has plasma which is a source of numerous infections and antibodies not native to the recipient.. Plasma of whole blood does NOT have any platelet , coagulation factors because stored blood at 2-8 C loses all the above components.. Dr Nishant Verma. Department of Pediatrics,. KGMU, Lucknow. Historical Time Line. 17. th. century- 1. st. recorded transfusion (from man to animal). 1901- Karl Landsteiner’s discovery of ABO grouping laid foundation for scientific transfusion practices. Blood transports everything (nutrients, wastes, and body heat). Blood is a complex fluid connective tissue with both solid and liquid components.. Solid – living blood cells (formed elements). Erythrocytes (red blood cells –RBCS). elements-Cells . Erythrocytes (RBCs). Leukocytes (WBCs). Thrombocytes. (platelets. ). Plasma. 90% water. 10% solutes. Proteins, clotting factors. 1. What can we give?. Whole blood. Packed RBC (PRBC). The heart is the pump that provides the major force causing blood to circulate and the blood vessels are the pipes that carry the blood to the tissues of the body and back to the heart. 2 major vessel types:. blood is collected as whole blood, as shown below:. Blood can be stored as whole blood (with all of the plasma present) or, much more commonly, as packed red blood cells (PRBC's) in which about 70% of the plasma has been removed.. Why to Irradiate blood. Transfusion Associated Graft versus Host Disease (TAGVHD). Indications of Irradiated Components. Shelf Life of Irradiated products. Methods of Irradiation. Contents. For Prevention of . Blood pressure log for your daily measurements. keeping track of your health.You can use this blood pressure log book send it directly to your doctor. Fluids of the Body . Cells of the body are serviced by 2 fluids. blood. composed of plasma and a variety of cells. transports nutrients and wastes. interstitial fluid. bathes the cells of the body. Nutrients and oxygen diffuse from the blood into the interstitial fluid & then into the cells. in BLOOD PRESSURE. Blood. . pressure. – . the. most . important. . parameter. in . cardiovascular. . system. – „. high. -profile“ . parameter. Blood. . pressure. (BP) – . pressure. 55% plasma. 45% cells . 99% RBCs. < 1% WBCs and platelets. Formed Elements of Blood. Red blood cells ( erythrocytes ). White blood cells ( leukocytes ). granular leukocytes. neutrophils. eosinophils. Erythrocytes (RBCs). Leukocytes (WBCs). Thrombocytes. (platelets). Plasma. 90% water. 10% solutes. Proteins, clotting factors. 1. What can we give?. Whole blood. Packed RBC (PRBC). Platelets. Fresh Frozen Plasma (FFP). Reverend Dr David CM Taylor. http:/www.liv.ac.uk/~dcmt. http://pcwww.liv.ac.uk/~dcmt/cvs10.ppt. intrinsic (Starling’s Law). extrinsic (principally autonomic). The story so far.... Stroke volume. Heart rate.