PPT-A novel synthetic antimicrobial peptide for the cure of Gram-negative infections. Mechanism

biodistribution and resistance selection Alessandro Pini piniaunisiit Department of Medical Biotechnology University of Siena Italy SetLance srl Toscana Life Sciences Italy The new AMP M33. بسم الله الرحمن الرحيم. Diagnostic Medical Microbiology-Laboratory Manual. Antimicrobial . Chemotherapy . to . Control Microorganisms. . Usually, microbial controls are used to avoid contamination of pure cultures, prevent infection, or treat existing diseases.. Part-2. Sulfur Dioxide(SO2) and Sulfites(SO3). Sulfur dioxide, Sodium sulfite(Na2SO3), Sodium bisulfide(NaHSO3), and Sodium . metabisulfite. (Na2S2O5) are used to control microorganisms and insects in soft fruits, lemon juices, beverages, sausages, pickles, and fresh shrimp.. biodistribution. and resistance selection. Alessandro . Pini. pinia@unisi.it. Department of Medical Biotechnology. University of Siena. Italy. SetLance srl. Toscana Life Sciences. Italy. The new AMP M33. biodistribution. and resistance selection. Alessandro . Pini. pinia@unisi.it. Department of Medical Biotechnology. University of Siena. Italy. SetLance srl. Toscana Life Sciences. Italy. The new AMP M33. Physical differences & clinical . signifigance. . . Figure 4.8b. Gram- positive bacteria. Gram-negative bacteria. Figure 4.8a. Gram-Positive cell walls. Teichoic acids:. Lipoteichoic acid links to plasma membrane. Diagnostic Medical Microbiology-Laboratory Manual. Antimicrobial . Chemotherapy . to . Control Microorganisms. . Usually, microbial controls are used to avoid contamination of pure cultures, prevent infection, or treat existing diseases.. Antimicrobial resistance . Did we lose the magic bullet?. U. Theuretzbacher – . C. enter . f. or . A. nti-. I. nfective . A. gents, Vienna, Austria. Conflict of interest. Nothing to disclose. Self-assessment questions. Gbadero D. A.. BUTH. Ogbomoso. Definition. Infections involving the meningeal coverings of CNS and the CNS parenchyma. Objectives. Learn. ing . about epidemiology of CNS infections. Understanding causes and basic pathology of CNS infections. : is the use of chemical agents (either synthetic or natural) to destroy . infective agents . (microorganisms’ . i.e. bacteria, fungus and viruses, protozoa, and helminthes) and . to inhibit . the growth of malignant or cancerous cells. DRUG ACTION: The penicillins are . bactericidal. and act by interfering with bacterial cell wall synthesis. They diffuse well into body tissues and fluids, but penetration into the cerebrospinal fluid is poor except when the meninges are inflamed. They are excreted in the urine in therapeutic concentrations.. Drugs. Folate-derived cofactors are essential for the synthesis of purines and other compounds necessary for cellular growth and replication. Therefore, in the absence of . folate. , cells cannot grow or divide. To synthesize the critical . . Mohammed. MBChB. . FIBMS . Patholoy. /. mico-immunopath. University of . Mustanisiriya. College of Medicine . Third stage . Anaerobic Bacterial Infection. Overview . Anaerobic . bacteria:. . Bacteria that do not use . Gram Positive. Gram Negative. Gram-Positive bacteria. Gram-Negative bacteria. Cell Wall. A single-layered, smooth cell wall.  A double-layered, wavy cell-wall. Cell Wall thickness. The thickness of the cell wall is 20 to 80 . (cont. ). Oula. Mohammed. M.B.Ch.B. / MSc. Clinical pharmacology. Cephalosporins. The . cephalosporins. are one of the . largest. and . most widely . used groups of antibiotics.. They are . β-lactam antibiotics .