PPT-Intro to Neuromuscular blocking agents

Done by Ahmad Al Masri Quick Cholinergic review acetylcholine ACH is neurotransmitter of the parasympathetic nervous system ACH is synthesized in the cholinergic neurons from choline and acetyl CoA then stored in synaptic vesicles then it will be release into synaptic gap to bind post synaptic . Journal . Club presenters: Drs. Ricky Harika, Sharanya Nama, Tom Talamo, Julie DeVore, and Andrew Gentilin. Neuromuscular Blockade and Post-Operative Respiratory Complications. EBM Statistics. Jim Ibinson. . Laura Lorenz. Mark Fischer . Larvingo. Alston . History . Native South America tribes smeared . a paste made from . Chondrodendron. . tomentosum. . on . blow darts and arrowheads to improve chances of obtaining wild game. . Physiology of Muscle Fibers. Action Potentials: The Role of Motor Neurons. Motor neurons . produce motion by interacting . with skeletal muscle.. Electric signals called . action potentials. are sent along nerve cells to muscle fibers.. (PNF). Objectives:. Describe a brief history of PNF.. Define PNF.. List the purposes of PNF.. Be able to apply PNF when working with patients.. Brief History of PNF . ¹. Mid-1940’s: Neurophysiologist Dr. Herman Kabat developed PNF to rehabilitate the muscles of polio patients. Overview of the Neuromuscular System . Nervous . system and muscles are working together to . allow movement . In order t. o . move a part. of . your . body, . a message is sent to particular nerve cells which are called upper motor neurons. . always. blocks?. always. blocks start when triggered and scan their statements sequentially. Blocking assignment: = (completes assignment before next statement executes). Non-blocking: <= (all such statements complete at once at end of the always block). Neuromuscular Blockers. Prevent acetylcholine from activating nicotinic. M. Cause muscle relaxation (paralysis). No oral forms. Cannot cross . Blood-brain barrier . No impact on CNS (paralysis, not sedation). Why segregate blocking and non-blocking assignments to separate always blocks? always blocks start when triggered and scan their statements sequentially Blocking assignment: = (completes assignment before next statement executes) Source:. . Anesthesiology . 6 2015, Vol.122, 1201-. 1213. . . http. ://. anesthesiology.pubs.asahq.org. /. Article.aspx?articleid. =. 2278676. Authors: Duncan J. McLean, . M.B.Ch.B. .; Daniel Diaz-Gil, . (NMBAs). A self-directed learning module for nurses. April, 2017. Learning Objectives. By successful completion of this self-directed learning (SDL) module and achieving a passing grade of 90% on the post-test, learners will have demonstrated:. Neuromuscular blockade in Critical Care. Aim. . To provide guidance on the administration and monitoring of neuromuscular blockade in Critical Care. Scope. All adult patients in intensive care receiving continuous neuromuscular blockade. that bind . to . cholinoceptors. (. muscarinic. . or nicotinic) . and prevent . the effects of . acetylcholine (. ACh. ) and . other . cholinergic agonists. The most clinically. useful of these agents are selective . . of. . Muscle. . Relaxants. Centrally. . active. Baclofen. Benzodiazepines. :. Tetrazepam . Diazepam. Clonazepam. Thiocolchicoside. Mephenoxalone. Tizanidine. Guaifenesin. Orphenadrine. Peripherally. October 2019. Michelle Coady. Neuromuscular Transmission . Skeletal muscle fibers are innervated by large, myelinated nerves . Nerve fibers branch out to stimulate several hundred skeletal muscle fibers.