PPT-New approaches for developing viral vaccines against influenza and respiratory syncytial

SangMoo Kang Georgia State University December 8 2015 Virology2015 Atlanta 1918 H1N1 The worst and greatest pandemic deaths of 40 to 100 million people worldwide Lung inflammation. 1. October 2013. Max Planck Institute Magdeburg. Options for continuous production of . cell culture-derived viral vaccines. MAX-PLANCK-INSTITUT. DYNAMIK KOMPLEXER. TECHNISCHER SYSTEME. MAGDEBURG. Frensing. 28 February 2020 Page 1 of 12 20 - 202 1 northern hemisphere influenza season February 20 20 WHO convenes technical consultations 1 in February and September each year to recommend viruses for inc Ananda. Kumar . Saha. Dept. of Zoology. Rajshahi. University . Viral Diseases. Viral. . diseases. . are structural . or . functional disorder of an organism caused . by . infection of viruses. .. Objectives. Review the New Jersey state influenza vaccination law and how it affects your healthcare facility. Discuss CDC recommendations for protecting staff and patients/residents during influenza season. 1. 2. RNA Viruses. Diverse group of microbes . Assigned to one of 12 families based on envelope, capsid, and nature of RNA genome. 3. Enveloped Segmented Single-Stranded RNA Viruses. Orthomyxoviruses. MD, PhD . General Consideration . Acute viral respiratory illnesses are among the most common of human diseases, accounting for one-half or more of all acute illnesses.. Influenza is an acute respiratory illness caused by infection with influenza viruses. . Avian influenza is viral disease affecting respiratory, digestive and / or nervous system of many species of birds .. Etiology . Orthomyxovirus. . type . A two . forms :-. 1- Highly . Pathogenic . RNA virus. of the family . Orthomyxoviridae. that is responsible for the infectious disease . influenza. (or most commonly referred to as flu) in birds, various mammals (such as pigs) and humans. Typically, influenza is characterized by fever, sore throat, chills and other non-specific symptoms, it is a much more severe disease. It is spread around the world in seasonal epidemics and according to World Health Organization, these annual epidemics result in about three to five million cases of severe illness, and about 250 000 to 500 000 deaths.. Reperant LA, van Amerongen G, van de Bildt MW, Rimmelzwaan GF, Dobson AP, Osterhaus A, et al. Highly Pathogenic Avian Influenza Virus (H5N1) Infection in Red Foxes Fed Infected Bird Carcasses. Emerg Infect Dis. 2008;14(12):1835-1841. https://doi.org/10.3201/eid1412.080470. Viral infections commonly affect the upper or lower respiratory tract. Although these infections can be classified by the causative virus (. eg. , influenza), they are generally classified clinically according to syndrome (. Viruses are very small – smaller than the smallest cell.. They are usually surrounded by a capsid of proteins.. For replication, viruses rely on their host cells . ie. ., the cells they infect.. Most viruses exhibit a limited host range- they typically infect only specific types of cells of one host species.. Pasick J, Berhane Y, Embury-Hyatt C, Copps J, Kehler H, Handel K, et al. Susceptibility of Canada Geese (Branta canadensis) to Highly Pathogenic Avian Influenza Virus (H5N1). Emerg Infect Dis. 2007;13(12):1821-1827. https://doi.org/10.3201/eid1312.070502. Belser JA, Bridges CB, Katz JM, Tumpey TM. Past, Present, and Possible Future Human Infection with Influenza Virus A Subtype H7. Emerg Infect Dis. 2009;15(6):859-865. https://doi.org/10.3201/eid1506.090072. S. Mark Tompkins, PhD. Center for Vaccines and Immunology. Department of Infectious Diseases. March 20, 2017. 1. Linda M. . Stannard. , University of Cape Town. Influenza viruses. 2. Influenza A virus.