PPT-Ubiquitination ® Post-translational modification of a protein by the covalent attachment

ubiquitin monomers The most prominent function of ubiquitin is labeling proteins for proteasomal degradation Ubiquitination also controls the stability function and intracellular localization of a wide variety of proteins . The classic principle of . protein folding. is that all the information required for a protein to adopt the correct three-dimensional conformation is provided by its amino acid sequence.. Molecular chaperones. VSEPR Theory, Polarity, and using . Electronegativity. Covalent . Bonds. Forms when 2 atoms share a pair of valence e. -. A. Types of Covalent Bonds. 1. . Single Covalent Bond . – two atoms share . Co = Together. The Octet Rule. The octet rule says that all atoms want to have eight valence electrons, like the noble gases.. One way that atoms can follow the octet rule is by giving and taking electrons… ionic bonding. Including Naming. Note: We likely won’t make it to covalent nomenclature, this is the one students find FAR easier than ionic. Please refer to the videos and naming hand out for help with this, and as always office hours, discussions, and . COVALENT BOND. bond. formed by the . sharing . of . electrons . Covalent . Bonds. Between nonmetallic elements of similar electronegativity. .. Electronegativity = how badly an atom wants to add an electron (non metals have higher electronegativity). Ball-and-stick model. Molecular . Compounds. OBJECTIVES:. Distinguish. between the melting points and boiling points of . molecular. compounds and . ionic. compounds.. Molecular . Compounds. OBJECTIVES:.  . 1) . SeF. 6. . . ________________________________________.  . 2) . TeO. 3 . . ________________________________________.  . 3) . H. 2. O. . . ________________________________________.  . Types of bonds. Ionic bonding. results from electrostatic attractions among ions, which are formed by the . transfer. of one or more electrons from one atom to another.. Covalent bonding. results from . Covalent Compounds. Formed between two non-metals. Valence electrons are shared between atoms. Binary Covalent Compounds. Contain just two different types of non-metal elements. Some Different Rules. (VICTR). VICTR Resources – . What’s New/What’s Next!. Tara . Helmer, PA-C, . MPH. Research Services . Consultant. Objectives. Vanderbilt Institute for Clinical and Translational Research . (VICTR). Mrs. Page. Essential Idea. Lewis (electron dot) structures show the electron domains in the valence shell and are used to predict molecular shape. .. Nature of Science. Scientists . use models as representatives of the real world – the development of the model of molecular shapes (VSEPR) to explain observable properties.. The UF-FSU hub is supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under University of Florida Clinical and Translational Science Awards UL1TR001427, KL2TR001429 and TL1TR001428.. Tiffanie Lee. Quantitative Biology. Dr. Brian . Strahl. , Department of Biochemistry and Biophysics. How does ASH1L read chromatin? What histone reader domains are involved in binding?. ASH1L and MLL cooperate to maintain hematopoiesis and transcription in immune cells in the blood. Routes to effective glycopolymer inhibitors of bacterial toxins. s. -j.richards@warwick.ac.uk. . Sarah-Jane Richards. and Matthew I. Gibson. Department of Chemistry, University of Warwick, UK. @. LabGibson.