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c Hard CODV HC I Microfiche MF T7   ff 653 July65 I UNITED STATES N c Hard CODV HC I Microfiche MF T7   ff 653 July65 I UNITED STATES N

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c Hard CODV HC I Microfiche MF T7 ff 653 July65 I UNITED STATES N - PPT Presentation

This research and Technology NAVAL AVIATION PENSACOLA FLORIDA any possible increase sickness drugs on the these drugs were tested alone included thiethylperazine a previous sickness drugs have been st ID: 896921

subjects drugs enter sickness drugs subjects sickness enter reported motion abstract tested increase report amphetamine x0000 previous drug increased

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1 c- Hard CODV (HC) I Microfiche (MF) T-7
c- Hard CODV (HC) I Microfiche (MF) T-7 _, - ff 653 July65 I UNITED STATES NAVAL SCHOOL OF AVIATION MEDICINE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION August 1965 ‘d Distribution of this document is unlimited. *This research and Technology, NAVAL AVIATION PENSACOLA, FLORIDA any possible inc

2 rease sickness drugs on the these drugs
rease sickness drugs on the these drugs were tested alone. included thiethylperazine a previous sickness drugs have been studied under difficulty of a standardized for a for testing these drugs on a a standardized these drugs to investigate their level subjects were subjects were subjected subjects w

3 ere cereal, and one and the experiment.
ere cereal, and one and the experiment. procedures were subjects were tested experiments were performed using also combined results were compared which involved Mecl izine subjects were to record rates were a scale adopted from enabled a to be subjects were to continually dials to at four-second reco

4 rder (Figure stimulation received recept
rder (Figure stimulation received receptors from and heave subjects were the subject's sickness. Two placebo run then taken before administration given periodi- subjects were except for observor who the combination a previous increased the average increase cent or an placebo level d-amphetamine increa

5 sed or by per cent. hyoscine increased c
sed or by per cent. hyoscine increased cent over the corresponding an increase failure to therapeutic effectiveness two exceptions trimethobenzamide (Tigan) than the 3 z 0 t- 4 N 9 9 a 0 c3 W 2w OCA 1) * �v E 0 I- a E �- v) a m i= .J = CA W � c I* a sow OSZ �I-0 .. El a a

6 W m 1 z .. clc w tn -.I z - a a I. El a
W m 1 z .. clc w tn -.I z - a a I. El a a W cn 1 z - a W I I- O J a #-I a a W cn 3 7 t=l tY 0 A 1 a n ## s w v) D 0 0 3 c3 7 I 0 I- W U - H U 0 13 a a W cn 3 z a U 0 1 1 n a El cn tn W z tn 0 - ? a n I I- - 4 0 0 + + Drugs Tested. Previous Study, questionnaire on are reported percentages to vision

7 , fatigue, produced a a greater and d-am
, fatigue, produced a a greater and d-amphetamine the largest to report stomach awareness. The drowsiness hyoscine alone. subject reported a to an headache from the questionnaire the subjects no side drug. Trirnethobenzamide (Tigan) had reported than considerable drowsi- reported. When and one reporte

8 d a to offer sickness drugs. The through
d a to offer sickness drugs. The through a the effectiveness sickness drugs. Such possible under study are and mecl to World shortly there- best drugs against motion present research dose. The future development sickness drugs. potency; however, these drugs greater effect except for the drug completed

9 and were the remaining drug combi- . 7
and were the remaining drug combi- . 7 parasympathetic nervous choline, the parasympathetics, produces the aforementioned action of the result contention by the report meclizine, thiethylperazine, trimethobenzamide, and also been on the factor that for motion effect with reported for on the on anti

10 motion sickness drugs significant differ
motion sickness drugs significant difference long held (1 1). be responsible for have been have been determine motion subjects and slight but for motion for testing no motion the head remained that received plane or 7:33-82, 1955. sickness. Proc. 52:965-972, 1959. and Wendt, 57:71-79, 1964. during pr

11 olonged and Kennedy, Than Recommended t
olonged and Kennedy, Than Recommended the Slow Rotation report and Kennedy, Robert numbers that on the Slow Rotation the present possible increase failed to effectiveness; however, d-amphetamine the exceeded the these drugs when tested alone. noted over d-amphetamine, and contractor, subcontractor,

12 grantee, Department other organization (
grantee, Department other organization (corporate security classification Automatic downgrading DoD Di- the group have been capitals in enter the type Give the inclusive reporting period middle initial. and branch principal author is an Enter the year; or month, one date on the pagination procedures,

13 references cited NUMBER: If grant under
references cited NUMBER: If grant under which Enter the military department document will to this NUMBER(S): If AVAILABILITY/LIMITATION NOTICES: other than by security classification, using standard statements “All distribution shall request and enter additional explana- tory notes. SPONSORING M

14 ILITARY ACTIVITY Enter project office 13
ILITARY ACTIVITY Enter project office 13. ABSTRACT: Enter an abstract a brief desirable that the abstract shall end on the the abstract. the suggested meaningful terms that characterize a report that no security designatlon. trade geographic location, an indication technical con- links. roles, and wei